Search Results
Overview
| Uniprot ID | O08795 |
|---|---|
| Protein Name | Glucosidase 2 subunit beta |
| Gene Name | Prkcsh |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | LLELQAGKKSLEDQV |
Function
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106, PubMed:9148925). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914)
Protein Sequence
10
MLLLLLLLLP
20
LCWAVEVKRP
30
RGVSLSNHHF
40
YEESKPFTCL
50
DGTATIPFDQ
60
VNDDYCDCKD
70
GSDEPGTAAC
80
PNGSFHCTNT
90
GYKPLYILSS
100
RVNDGVCDCC
110
DGTDEYNSGT
120
VCENTCREKG
130
RKEKESLQQL
140
AEVTREGFRL
150
KKILIEEWKT
160
AREEKQSKLL
170
ELQAGKKSLE
180
DQVETLRAAK
190
EEAERPEKEA
200
KDQHRKLWEE
210
QQAAAKARRE
220
QERAASAFQE
230
LDDNMDGMVS
240
LAELQTHPEL
250
DTDGDGALSE
260
EEAQALLSGD
270
TQTDTTSFYD
280
RVWAAIRDKY
290
RSEVPPTDIP
300
VPEETEPKEE
310
KPPVLPPTEE
320
EEEEEEEPEE
330
EEEEEEEEEE
340
APPPLQPPQP
350
PSPTEDEKMP
360
PYDEETQAII
370
DAAQEARSKF
380
EEVERSLKEM
390
EESIRSLEQE
400
ISFDFGPSGE
410
FAYLYSQCYE
420
LTTNEYVYRL
430
CPFKLVSQKP
440
KHGGSPTSLG
450
TWGSWAGPDH
460
DKFSAMKYEQ
470
GTGCWQGPNR
480
STTVRLLCGK
490
ETVVTSTTEP
500
SRCEYLMELM
510
TPAACPEPPP
520
EAPSDGDHDE
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0017177 | glucosidase II complex |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0006491 | N-glycan processing |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0071941 | nitrogen cycle metabolic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.