Search Results
Overview
| Uniprot ID | O08837 |
|---|---|
| Protein Name | Cell division cycle 5-like protein |
| Gene Name | Cdc5l |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 290 | SGVSEFTKKRSKLVL |
Function
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Protein Sequence
10
MPRIMIKGGV
20
WRNTEDEILK
30
AAVMKYGKNQ
40
WSRIASLLHR
50
KSAKQCKARW
60
YEWLDPSIKK
70
TEWSREEEEK
80
LLHLAKLMPT
90
QWRTIAPIIG
100
RTAAQCLEHY
110
EFLLDKTAQR
120
DNEEETTDDP
130
RKLKPGEIDP
140
NPETKPARPD
150
PIDMDEDELE
160
MLSEARARLA
170
NTQGKKAKRK
180
AREKQLEEAR
190
RLAALQKRRE
200
LRAAGIEIQK
210
KRKKKRGVDY
220
NAEIPFEKKP
230
ALGFYDTSEE
240
NYQALDADFR
250
KLRQQDLDGE
260
LRSEKEGRDR
270
KKDKQHLKRK
280
KESDLPSAIL
290
QTSGVSEFTK
300
KRSKLVLPAP
310
QISDAELQEV
320
VKVGQASEVA
330
RQTAEESGIT
340
NSASSTLLSE
350
YNVTNNSIAL
360
RTPRTPASQD
370
RILQEAQNLM
380
ALTNVDTPLK
390
GGLNTPLHES
400
DFSGVTPQRQ
410
VVQTPNTVLS
420
TPFRTPSNGA
430
EGLTPRSGTT
440
PKPVTNATPG
450
RTPLRDKLNI
460
NPEDGMADYS
470
DPSYVKQMER
480
ESREHLRLGL
490
LGLPAPKNDF
500
EIVLPENAEK
510
ELEEREMDDT
520
YIEDAADVDA
530
RKQAIRDAER
540
VKEMKRMHKA
550
VQKDLPRPSE
560
VNETILRPLN
570
VEPPLTDLQK
580
SEELIKKEMI
590
TMLHYDLLHH
600
PYEPSGNKKG
610
KNVGFATNNS
620
EHITYLEHSP
630
YEKFSKEDLK
640
KAQDVLVQEM
650
EVVKQGMSHG
660
ELSSEAYNQV
670
WEECYSQVLY
680
LPAQSRYTRA
690
NLASKKDRIE
700
SLEKRLEINR
710
GHMTTEAKRA
720
AKMEKKMKIL
730
LGGYQSRAMG
740
LLKQLNDLWD
750
QIEQAHLELR
760
TFEELKKHED
770
SAIPRRLECL
780
KEDVQRQQER
790
EKELQQRYAD
800
LLMEKETLQA
KF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Molecular Function | GO:0008157 | protein phosphatase 1 binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Molecular Function | GO:0071987 | WD40-repeat domain binding |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071352 | cellular response to interleukin-2 |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:1990646 | cellular response to prolactin |
| Biological Process | GO:1904568 | cellular response to wortmannin |
| Biological Process | GO:0000077 | DNA damage checkpoint signaling |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005662 | DNA replication factor A complex |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0071014 | post-mRNA release spliceosomal complex |
| Cellular Component | GO:0071020 | post-spliceosomal complex |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071018 | U12-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043522 | leucine zipper domain binding |
| Molecular Function | GO:0019901 | protein kinase binding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.