Search Results
Overview
| Uniprot ID | O08839 |
|---|---|
| Protein Name | Myc box-dependent-interacting protein 1 |
| Gene Name | Bin1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | SKGVTAGKIASNVQK |
| 146 | RIAKRGRKLVDYDSA |
| 164 | YESLQTAKKKDEAKI |
| 173 | KDEAKIAKPVSLLEK |
| 189 | APQWCQGKLQAHLVA |
| 211 | QAEEELIKAQKVFEE |
| 28 | KLTRAQEKVLQKLGK |
| 32 | AQEKVLQKLGKADET |
| 338 | KSPSQLRKGPPVPPP |
| 352 | PPKHTPSKEMKQEQI |
| 7 | *MAEMGSKGVTAGKI |
| 73 | RTYLASVKAMHEASK |
Function
Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:27760323, PubMed:9736607). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity)
Protein Sequence
10
MAEMGSKGVT
20
AGKIASNVQK
30
KLTRAQEKVL
40
QKLGKADETK
50
DEQFEQCVQN
60
FNKQLTEGTR
70
LQKDLRTYLA
80
SVKAMHEASK
90
KLSECLQEVY
100
EPEWPGRDEA
110
NKIAENNDLL
120
WMDYHQKLVD
130
QALLTMDTYL
140
GQFPDIKSRI
150
AKRGRKLVDY
160
DSARHHYESL
170
QTAKKKDEAK
180
IAKPVSLLEK
190
AAPQWCQGKL
200
QAHLVAQTNL
210
LRNQAEEELI
220
KAQKVFEEMN
230
VDLQEELPSL
240
WNSRVGFYVN
250
TFQSIAGLEE
260
NFHKEMSKLN
270
QNLNDVLVSL
280
EKQHGSNTFT
290
VKAQPSDSAP
300
EKGNKSPSPP
310
PDGSPAATPE
320
IRVNHEPEPA
330
SGASPGATIP
340
KSPSQLRKGP
350
PVPPPPKHTP
360
SKEMKQEQIL
370
SLFDDAFVPE
380
ISVTTPSQFE
390
APGPFSEQAS
400
LLDLDFEPLP
410
PVASPVKAPT
420
PSGQSIPWDL
430
WEPTESQAGV
440
LPSGEPSSAE
450
GSFAVAWPSQ
460
TAEPGPAQPA
470
EASEVVGGTQ
480
EPGETAASEA
490
TSSSLPAVVV
500
ETFSATVNGA
510
VEGSTTTGRL
520
DLPPGFMFKV
530
QAQHDYTATD
540
TDELQLKAGD
550
VVLVIPFQNP
560
EEQDEGWLMG
570
VKESDWNQHK
580
ELEKCRGVFP
ENFTERVQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0043194 | axon initial segment |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0044300 | cerebellar mossy fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0098850 | extrinsic component of synaptic vesicle membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0060987 | lipid tube |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0033268 | node of Ranvier |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0090571 | RNA polymerase II transcription repressor complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0043196 | varicosity |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019828 | aspartic-type endopeptidase inhibitor activity |
| Molecular Function | GO:0051020 | GTPase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0070063 | RNA polymerase binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Biological Process | GO:0008333 | endosome to lysosome transport |
| Biological Process | GO:0060988 | lipid tube assembly |
| Biological Process | GO:0042692 | muscle cell differentiation |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:1904878 | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process | GO:1901380 | negative regulation of potassium ion transmembrane transport |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1903946 | negative regulation of ventricular cardiac muscle cell action potential |
| Biological Process | GO:0051647 | nucleus localization |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0048711 | positive regulation of astrocyte differentiation |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0010564 | regulation of cell cycle process |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0033292 | T-tubule organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.