Search Results
Overview
| Uniprot ID | O09161 |
|---|---|
| Protein Name | Calsequestrin-2 |
| Gene Name | Casq2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | RVVSLSEKNLKQMLK |
Function
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats
Protein Sequence
10
MKRIYLLMVG
20
VYLLSLSGAE
30
EGLNFPTYDG
40
KDRVVSLSEK
50
NLKQMLKRYD
60
LLCLYYHEPV
70
SSDKVSQKQF
80
QLKEIVLELV
90
AQVLEHKNIG
100
FVMVDSRKEA
110
KLAKRLGFSE
120
EGSLYVLKGD
130
RTIEFDGEFA
140
ADVLVEFLLD
150
LIEDPVEIVN
160
NKLEVQAFER
170
IEDQTKLLGF
180
FKNEDSEYYK
190
AFQEAAEHFQ
200
PYIKFFATFD
210
KAVAKKLSLK
220
MNEVGFYEPF
230
MDEPNVIPNK
240
PYTEEELVEF
250
VKEHQRPTLR
260
RLRPEDMFET
270
WEDDLNGIHI
280
VAFAEKSDPD
290
GYEFLEILKQ
300
VARDNTDNPD
310
LSILWIDPDD
320
FPLLVAYWEK
330
TFKIDLFKPQ
340
IGVVNVTDAD
350
SIWMEIPDDD
360
DLPTAEELED
370
WIEDVLSGKI
380
NTEDDDNEDE
390
DDDGDDNDDD
400
DDDDDDNDNS
410
DEDNEDSDDD
DDDDE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030314 | junctional membrane complex |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0140314 | calcium ion sequestering activity |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0071313 | cellular response to caffeine |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0043267 | negative regulation of potassium ion transport |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0086004 | regulation of cardiac muscle cell contraction |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0010649 | regulation of cell communication by electrical coupling |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0060306 | regulation of membrane repolarization |
| Biological Process | GO:1905024 | regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0051208 | sequestering of calcium ion |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.