Search Results
Overview
| Uniprot ID | O09165 |
|---|---|
| Protein Name | Calsequestrin-1 |
| Gene Name | Casq1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | FGLVDSEKDAAVAKK |
| 55 | RVINVNAKNYKNVFK |
Function
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (By similarity). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity)
Protein Sequence
10
MRATDRMGAR
20
AVSELRLALL
30
FVLVLGTPRL
40
GVQGEDGLDF
50
PEYDGVDRVI
60
NVNAKNYKNV
70
FKKYEVLALL
80
YHEPPEDDKA
90
SQRQFEMEEL
100
ILELAAQVLE
110
DKGVGFGLVD
120
SEKDAAVAKK
130
LGLTEEDSVY
140
VFKGDEVIEY
150
DGEFSADTLV
160
EFLLDVLEDP
170
VELIEGEREL
180
QAFENIEDEI
190
KLIGYFKSKD
200
SEHYKAYEDA
210
AEEFHPYIPF
220
FATFDSKVAK
230
KLTLKLNEID
240
FYEAFMEEPM
250
TIPDKPNSEE
260
EIVSFVEEHR
270
RSTLRKLKPE
280
SMYETWEDDL
290
DGIHIVAFAE
300
EADPDGYEFL
310
ETLKAVAQDN
320
TENPDLSIIW
330
IDPDDFPLLV
340
PYWEKTFDID
350
LSAPQIGVVN
360
VTDADSIWME
370
MDNEEDLPSA
380
DELEDWLEDV
390
LEGEINTEDD
400
DDDDDDDDDD
DDDDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0014802 | terminal cisterna |
| Cellular Component | GO:0014804 | terminal cisterna lumen |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0007029 | endoplasmic reticulum organization |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:1901341 | positive regulation of store-operated calcium channel activity |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0051282 | regulation of sequestering of calcium ion |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:2001256 | regulation of store-operated calcium entry |
| Biological Process | GO:0014894 | response to denervation involved in regulation of muscle adaptation |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0014701 | junctional sarcoplasmic reticulum membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Cellular Component | GO:0030315 | T-tubule |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.