Search Results

Overview

Uniprot IDO14497
Protein NameAT-rich interactive domain-containing protein 1A
Gene NameARID1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1124 IFAAADSKKSQPKIQ
1125 FAAADSKKSQPKIQP
1201 GSDSTFQKRNSMTPN
1230 RMSYEPNKDPYGSMR
1612 PFLHSGMKMQKAGPP
1615 HSGMKMQKAGPPVPA
980 VKLTPATKMNNKADG
984 PATKMNNKADGTPKT

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)

Protein Sequence

10 MAAQVAPAAA 20 SSLGNPPPPP 30 PSELKKAEQQ 40 QREEAGGEAA 50 AAAAAERGEM 60 KAAAGQESEG 70 PAVGPPQPLG 80 KELQDGAESN 90 GGGGGGGAGS 100 GGGPGAEPDL 110 KNSNGNAGPR 120 PALNNNLTEP 130 PGGGGGGSSD 140 GVGAPPHSAA 150 AALPPPAYGF 160 GQPYGRSPSA 170 VAAAAAAVFH 180 QQHGGQQSPG 190 LAALQSGGGG 200 GLEPYAGPQQ 210 NSHDHGFPNH 220 QYNSYYPNRS 230 AYPPPAPAYA 240 LSSPRGGTPG 250 SGAAAAAGSK 260 PPPSSSASAS 270 SSSSSFAQQR 280 FGAMGGGGPS 290 AAGGGTPQPT 300 ATPTLNQLLT 310 SPSSARGYQG 320 YPGGDYSGGP 330 QDGGAGKGPA 340 DMASQCWGAA 350 AAAAAAAAAS 360 GGAQQRSHHA 370 PMSPGSSGGG 380 GQPLARTPQP 390 SSPMDQMGKM 400 RPQPYGGTNP 410 YSQQQGPPSG 420 PQQGHGYPGQ 430 PYGSQTPQRY 440 PMTMQGRAQS 450 AMGGLSYTQQ 460 IPPYGQQGPS 470 GYGQQGQTPY 480 YNQQSPHPQQ 490 QQPPYSQQPP 500 SQTPHAQPSY 510 QQQPQSQPPQ 520 LQSSQPPYSQ 530 QPSQPPHQQS 540 PAPYPSQQST 550 TQQHPQSQPP 560 YSQPQAQSPY 570 QQQQPQQPAP 580 STLSQQAAYP 590 QPQSQQSQQT 600 AYSQQRFPPP 610 QELSQDSFGS 620 QASSAPSMTS 630 SKGGQEDMNL 640 SLQSRPSSLP 650 DLSGSIDDLP 660 MGTEGALSPG 670 VSTSGISSSQ 680 GEQSNPAQSP 690 FSPHTSPHLP 700 GIRGPSPSPV 710 GSPASVAQSR 720 SGPLSPAAVP 730 GNQMPPRPPS 740 GQSDSIMHPS 750 MNQSSIAQDR 760 GYMQRNPQMP 770 QYSSPQPGSA 780 LSPRQPSGGQ 790 IHTGMGSYQQ 800 NSMGSYGPQG 810 GQYGPQGGYP 820 RQPNYNALPN 830 ANYPSAGMAG 840 GINPMGAGGQ 850 MHGQPGIPPY 860 GTLPPGRMSH 870 ASMGNRPYGP 880 NMANMPPQVG 890 SGMCPPPGGM 900 NRKTQETAVA 910 MHVAANSIQN 920 RPPGYPNMNQ 930 GGMMGTGPPY 940 GQGINSMAGM 950 INPQGPPYSM 960 GGTMANNSAG 970 MAASPEMMGL 980 GDVKLTPATK 990 MNNKADGTPK 1000 TESKSKKSSS 1010 STTTNEKITK 1020 LYELGGEPER 1030 KMWVDRYLAF 1040 TEEKAMGMTN 1050 LPAVGRKPLD 1060 LYRLYVSVKE 1070 IGGLTQVNKN 1080 KKWRELATNL 1090 NVGTSSSAAS 1100 SLKKQYIQCL 1110 YAFECKIERG 1120 EDPPPDIFAA 1130 ADSKKSQPKI 1140 QPPSPAGSGS 1150 MQGPQTPQST 1160 SSSMAEGGDL 1170 KPPTPASTPH 1180 SQIPPLPGMS 1190 RSNSVGIQDA 1200 FNDGSDSTFQ 1210 KRNSMTPNPG 1220 YQPSMNTSDM 1230 MGRMSYEPNK 1240 DPYGSMRKAP 1250 GSDPFMSSGQ 1260 GPNGGMGDPY 1270 SRAAGPGLGN 1280 VAMGPRQHYP 1290 YGGPYDRVRT 1300 EPGIGPEGNM 1310 STGAPQPNLM 1320 PSNPDSGMYS 1330 PSRYPPQQQQ 1340 QQQQRHDSYG 1350 NQFSTQGTPS 1360 GSPFPSQQTT 1370 MYQQQQQNYK 1380 RPMDGTYGPP 1390 AKRHEGEMYS 1400 VPYSTGQGQP 1410 QQQQLPPAQP 1420 QPASQQQAAQ 1430 PSPQQDVYNQ 1440 YGNAYPATAT 1450 AATERRPAGG 1460 PQNQFPFQFG 1470 RDRVSAPPGT 1480 NAQQNMPPQM 1490 MGGPIQASAE 1500 VAQQGTMWQG 1510 RNDMTYNYAN 1520 RQSTGSAPQG 1530 PAYHGVNRTD 1540 EMLHTDQRAN 1550 HEGSWPSHGT 1560 RQPPYGPSAP 1570 VPPMTRPPPS 1580 NYQPPPSMQN 1590 HIPQVSSPAP 1600 LPRPMENRTS 1610 PSKSPFLHSG 1620 MKMQKAGPPV 1630 PASHIAPAPV 1640 QPPMIRRDIT 1650 FPPGSVEATQ 1660 PVLKQRRRLT 1670 MKDIGTPEAW 1680 RVMMSLKSGL 1690 LAESTWALDT 1700 INILLYDDNS 1710 IMTFNLSQLP 1720 GLLELLVEYF 1730 RRCLIEIFGI 1740 LKEYEVGDPG 1750 QRTLLDPGRF 1760 SKVSSPAPME 1770 GGEEEEELLG 1780 PKLEEEEEEE 1790 VVENDEEIAF 1800 SGKDKPASEN 1810 SEEKLISKFD 1820 KLPVKIVQKN 1830 DPFVVDCSDK 1840 LGRVQEFDSG 1850 LLHWRIGGGD 1860 TTEHIQTHFE 1870 SKTELLPSRP 1880 HAPCPPAPRK 1890 HVTTAEGTPG 1900 TTDQEGPPPD 1910 GPPEKRITAT 1920 MDDMLSTRSS 1930 TLTEDGAKSS 1940 EAIKESSKFP 1950 FGISPAQSHR 1960 NIKILEDEPH 1970 SKDETPLCTL 1980 LDWQDSLAKR 1990 CVCVSNTIRS 2000 LSFVPGNDFE 2010 MSKHPGLLLI 2020 LGKLILLHHK 2030 HPERKQAPLT 2040 YEKEEEQDQG 2050 VSCNKVEWWW 2060 DCLEMLRENT 2070 LVTLANISGQ 2080 LDLSPYPESI 2090 CLPVLDGLLH 2100 WAVCPSAEAQ 2110 DPFSTLGPNA 2120 VLSPQRLVLE 2130 TLSKLSIQDN 2140 NVDLILATPP 2150 FSRLEKLYST 2160 MVRFLSDRKN 2170 PVCREMAVVL 2180 LANLAQGDSL 2190 AARAIAVQKG 2200 SIGNLLGFLE 2210 DSLAATQFQQ 2220 SQASLLHMQN 2230 PPFEPTSVDM 2240 MRRAARALLA 2250 LAKVDENHSE 2260 FTLYESRLLD 2270 ISVSPLMNSL 2280 VSQVICDVLF LIGQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035060 brahma complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0071565 nBAF complex
Cellular Component GO:0071564 npBAF complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016514 SWI/SNF complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0007399 nervous system development
Biological Process GO:0006337 nucleosome disassembly
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:2000781 positive regulation of double-strand break repair
Biological Process GO:0045663 positive regulation of myoblast differentiation
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Biological Process GO:0045582 positive regulation of T cell differentiation
Biological Process GO:0070316 regulation of G0 to G1 transition
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0030071 regulation of mitotic metaphase/anaphase transition
Biological Process GO:2000819 regulation of nucleotide-excision repair
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0045815 transcription initiation-coupled chromatin remodeling

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.