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Overview

Uniprot ID	O14530
Protein Name	Thioredoxin domain-containing protein 9
Gene Name	TXNDC9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
201	PPFQNQKKFGTNFTK
208	KFGTNFTKLEKKTIR

Function

Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin

Protein Sequence

10 MEADASVDMF 20 SKVLEHQLLQ 30 TTKLVEEHLD 40 SEIQKLDQMD 50 EDELERLKEK 60 RLQALRKAQQ 70 QKQEWLSKGH 80 GEYREIPSER 90 DFFQEVKESE 100 NVVCHFYRDS 110 TFRCKILDRH 120 LAILSKKHLE 130 TKFLKLNVEK 140 APFLCERLHI 150 KVIPTLALLK 160 DGKTQDYVVG 170 FTDLGNTDDF 180 TTETLEWRLG 190 SSDILNYSGN 200 LMEPPFQNQK 210 KFGTNFTKLE 220 KKTIRGKKYD SDSDDD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0045296	cadherin binding
Biological Process	GO:0000226	microtubule cytoskeleton organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.