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Overview

Uniprot ID	O14531
Protein Name	Dihydropyrimidinase-related protein 4
Gene Name	DPYSL4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
525	ARASCPGKISVPPVR

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Protein Sequence

10 MSFQGKKSIP 20 RITSDRLLIR 30 GGRIVNDDQS 40 FYADVHVEDG 50 LIKQIGENLI 60 VPGGIKTIDA 70 HGLMVLPGGV 80 DVHTRLQMPV 90 LGMTPADDFC 100 QGTKAALAGG 110 TTMILDHVFP 120 DTGVSLLAAY 130 EQWRERADSA 140 ACCDYSLHVD 150 ITRWHESIKE 160 ELEALVKEKG 170 VNSFLVFMAY 180 KDRCQCSDSQ 190 MYEIFSIIRD 200 LGALAQVHAE 210 NGDIVEEEQK 220 RLLELGITGP 230 EGHVLSHPEE 240 VEAEAVYRAV 250 TIAKQANCPL 260 YVTKVMSKGA 270 ADAIAQAKRR 280 GVVVFGEPIT 290 ASLGTDGSHY 300 WSKNWAKAAA 310 FVTSPPVNPD 320 PTTADHLTCL 330 LSSGDLQVTG 340 SAHCTFTTAQ 350 KAVGKDNFAL 360 IPEGTNGIEE 370 RMSMVWEKCV 380 ASGKMDENEF 390 VAVTSTNAAK 400 IFNFYPRKGR 410 VAVGSDADLV 420 IWNPKATKII 430 SAKTHNLNVE 440 YNIFEGVECR 450 GAPAVVISQG 460 RVALEDGKMF 470 VTPGAGRFVP 480 RKTFPDFVYK 490 RIKARNRLAE 500 IHGVPRGLYD 510 GPVHEVMVPA 520 KPGSGAPARA 530 SCPGKISVPP 540 VRNLHQSGFS 550 LSGSQADDHI 560 ARRTAQKIMA 570 PPGGRSNITS LS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0031005	filamin binding
Molecular Function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process	GO:0007399	nervous system development

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.