Search Results
Overview
| Uniprot ID | O14545 |
|---|---|
| Protein Name | TRAF-type zinc finger domain-containing protein 1 |
| Gene Name | TRAFD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 485 | PSSPCVPKLSNSDSQ |
Function
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)
Protein Sequence
10
MAEFLDDQET
20
RLCDNCKKEI
30
PVFNFTIHEI
40
HCQRNIGMCP
50
TCKEPFPKSD
60
METHMAAEHC
70
QVTCKCNKKL
80
EKRLLKKHEE
90
TECPLRLAVC
100
QHCDLELSIL
110
KLKEHEDYCG
120
ARTELCGNCG
130
RNVLVKDLKT
140
HPEVCGREGE
150
EKRNEVAIPP
160
NAYDESWGQD
170
GIWIASQLLR
180
QIEALDPPMR
190
LPRRPLRAFE
200
SDVFHNRTTN
210
QRNITAQVSI
220
QNNLFEEQER
230
QERNRGQQPP
240
KEGGEESANL
250
DFMLALSLQN
260
EGQASSVAEQ
270
DFWRAVCEAD
280
QSHGGPRSLS
290
DIKGAADEIM
300
LPCEFCEELY
310
PEELLIDHQT
320
SCNPSRALPS
330
LNTGSSSPRG
340
VEEPDVIFQN
350
FLQQAASNQL
360
DSLMGLSNSH
370
PVEESIIIPC
380
EFCGVQLEEE
390
VLFHHQDQCD
400
QRPATATNHV
410
TEGIPRLDSQ
420
PQETSPELPR
430
RRVRHQGDLS
440
SGYLDDTKQE
450
TANGPTSCLP
460
PSRPINNMTA
470
TYNQLSRSTS
480
GPRPGCQPSS
490
PCVPKLSNSD
500
SQDIQGRNRD
510
SQNGAIAPGH
520
VSVIRPPQNL
530
YPENIVPSFS
540
PGPSGRYGAS
550
GRSEGGRNSR
560
VTPAAANYRS
570
RTAKAKPSKQ
580
QGAGDAEEEE
EE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045824 | negative regulation of innate immune response |
Reference
PMID: N/A