Overview
| Uniprot ID | O14548 |
|---|
| Protein Name | Cytochrome c oxidase subunit 7A2-like, mitochondrial |
|---|
| Gene Name | COX7A2L |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 65 |
NKVPELQKFFQKADG |
| 69 |
ELQKFFQKADGVPVY |
Function
Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism (PubMed:27545886, PubMed:30428348, PubMed:33727070, PubMed:36198313). Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association (PubMed:27545886, PubMed:36198313). Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV (PubMed:27545886, PubMed:30428348). Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (By similarity). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis (PubMed:36198313)
Protein Sequence
10
MYYKFSGFTQ
20
KLAGAWASEA
30
YSPQGLKPVV
40
STEAPPIIFA
50
TPTKLTSDST
60
VYDYAGKNKV
70
PELQKFFQKA
80
DGVPVYLKRG
90
LPDQMLYRTT
100
MALTVGGTIY
110
CLIALYMASQ
PKNK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0004129 |
cytochrome-c oxidase activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
| Biological Process |
GO:0097250 |
mitochondrial respirasome assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.