Search Results
Overview
| Uniprot ID | O14556 |
|---|---|
| Protein Name | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific |
| Gene Name | GAPDHS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | DSTHGRYKGSVEFRN |
| 151 | EISVYQCKEPKQIPW |
| 154 | VYQCKEPKQIPWRAV |
| 258 | HSYTATQKTVDGPSR |
| 287 | PASTGAAKAVTKVIP |
| 291 | GAAKAVTKVIPELKG |
| 297 | TKVIPELKGKLTGMA |
| 299 | VIPELKGKLTGMAFR |
| 331 | PAPYSAIKEAVKAAA |
| 97 | VLRACMEKGVKVVAV |
Function
Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)
Protein Sequence
10
MSKRDIVLTN
20
VTVVQLLRQP
30
CPVTRAPPPP
40
EPKAEVEPQP
50
QPEPTPVREE
60
IKPPPPPLPP
70
HPATPPPKMV
80
SVARELTVGI
90
NGFGRIGRLV
100
LRACMEKGVK
110
VVAVNDPFID
120
PEYMVYMFKY
130
DSTHGRYKGS
140
VEFRNGQLVV
150
DNHEISVYQC
160
KEPKQIPWRA
170
VGSPYVVEST
180
GVYLSIQAAS
190
DHISAGAQRV
200
VISAPSPDAP
210
MFVMGVNEND
220
YNPGSMNIVS
230
NASCTTNCLA
240
PLAKVIHERF
250
GIVEGLMTTV
260
HSYTATQKTV
270
DGPSRKAWRD
280
GRGAHQNIIP
290
ASTGAAKAVT
300
KVIPELKGKL
310
TGMAFRVPTP
320
DVSVVDLTCR
330
LAQPAPYSAI
340
KEAVKAAAKG
350
PMAGILAYTE
360
DEVVSTDFLG
370
DTHSSIFDAK
380
AGIALNDNFV
390
KLISWYDNEY
400
GYSHRVVDLL
RYMFSRDK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.