Overview
| Uniprot ID | O14579 |
|---|
| Protein Name | Coatomer subunit epsilon |
|---|
| Gene Name | COPE |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 293 |
FIKEYQAKENDFDRL |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)
Protein Sequence
10
MAPPAPGPAS
20
GGSGEVDELF
30
DVKNAFYIGS
40
YQQCINEAQR
50
VKLSSPERDV
60
ERDVFLYRAY
70
LAQRKFGVVL
80
DEIKPSSAPE
90
LQAVRMFADY
100
LAHESRRDSI
110
VAELDREMSR
120
SVDVTNTTFL
130
LMAASIYLHD
140
QNPDAALRAL
150
HQGDSLECTA
160
MTVQILLKLD
170
RLDLARKELK
180
RMQDLDEDAT
190
LTQLATAWVS
200
LATGGEKLQD
210
AYYIFQEMAD
220
KCSPTLLLLN
230
GQAACHMAQG
240
RWEAAEGLLQ
250
EALDKDSGYP
260
ETLVNLIVLS
270
QHLGKPPEVT
280
NRYLSQLKDA
290
HRSHPFIKEY
300
QAKENDFDRL
VLQYAPSA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030126 |
COPI vesicle coat |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0006891 |
intra-Golgi vesicle-mediated transport |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.