Search Results
Overview
| Uniprot ID | O14613 |
|---|---|
| Protein Name | Cdc42 effector protein 2 |
| Gene Name | CDC42EP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | TKVPIYLKRGSRKGK |
Function
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner
Protein Sequence
10
MSTKVPIYLK
20
RGSRKGKKEK
30
LRDLLSSDMI
40
SPPLGDFRHT
50
IHIGSGGGSD
60
MFGDISFLQG
70
KFHLLPGTMV
80
EGPEEDGTFD
90
LPFQFTRTAT
100
VCGRELPDGP
110
SPLLKNAISL
120
PVIGGPQALT
130
LPTAQAPPKP
140
PRLHLETPQP
150
SPQEGGSVDI
160
WRIPETGSPN
170
SGLTPESGAE
180
EPFLSNASSL
190
LSLHVDLGPS
200
ILDDVLQIMD
210
QDLDSMQIPT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0001515 | opioid peptide activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0031274 | positive regulation of pseudopodium assembly |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0007266 | Rho protein signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.