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Overview

Uniprot ID	O14617
Protein Name	AP-3 complex subunit delta-1
Gene Name	AP3D1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
654	EEEQRRPKHRPSEAD
7	*MALKMVKGSIDRMF
820	SEKLPIQKHRNTETS

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity)

Protein Sequence

10 MALKMVKGSI 20 DRMFDKNLQD 30 LVRGIRNHKE 40 DEAKYISQCI 50 DEIKQELKQD 60 NIAVKANAVC 70 KLTYLQMLGY 80 DISWAAFNII 90 EVMSASKFTF 100 KRIGYLAASQ 110 SFHEGTDVIM 120 LTTNQIRKDL 130 SSPSQYDTGV 140 ALTGLSCFVT 150 PDLARDLAND 160 IMTLMSHTKP 170 YIRKKAVLIM 180 YKVFLKYPES 190 LRPAFPRLKE 200 KLEDPDPGVQ 210 SAAVNVICEL 220 ARRNPKNYLS 230 LAPLFFKLMT 240 SSTNNWVLIK 250 IIKLFGALTP 260 LEPRLGKKLI 270 EPLTNLIHST 280 SAMSLLYECV 290 NTVIAVLISL 300 SSGMPNHSAS 310 IQLCVQKLRI 320 LIEDSDQNLK 330 YLGLLAMSKI 340 LKTHPKSVQS 350 HKDLILQCLD 360 DKDESIRLRA 370 LDLLYGMVSK 380 KNLMEIVKKL 390 MTHVDKAEGT 400 TYRDELLTKI 410 IDICSQSNYQ 420 YITNFEWYIS 430 ILVELTRLEG 440 TRHGHLIAAQ 450 MLDVAIRVKA 460 IRKFAVSQMS 470 ALLDSAHLLA 480 SSTQRNGICE 490 VLYAAAWICG 500 EFSEHLQEPH 510 HTLEAMLRPR 520 VTTLPGHIQA 530 VYVQNVVKLY 540 ASILQQKEQA 550 GEAEGAQAVT 560 QLMVDRLPQF 570 VQSADLEVQE 580 RASCILQLVK 590 HIQKLQAKDV 600 PVAEEVSALF 610 AGELNPVAPK 620 AQKKVPVPEG 630 LDLDAWINEP 640 LSDSESEDER 650 PRAVFHEEEQ 660 RRPKHRPSEA 670 DEEELARRRE 680 ARKQEQANNP 690 FYIKSSPSPQ 700 KRYQDTPGVE 710 HIPVVQIDLS 720 VPLKVPGLPM 730 SDQYVKLEEE 740 RRHRQKLEKD 750 KRRKKRKEKE 760 KKGKRRHSSL 770 PTESDEDIAP 780 AQQVDIVTEE 790 MPENALPSDE 800 DDKDPNDPYR 810 ALDIDLDKPL 820 ADSEKLPIQK 830 HRNTETSKSP 840 EKDVPMVEKK 850 SKKPKKKEKK 860 HKEKERDKEK 870 KKEKEKKKSP 880 KPKKKKHRKE 890 KEERTKGKKK 900 SKKQPPGSEE 910 AAGEPVQNGA 920 PEEEQLPPES 930 SYSLLAENSY 940 VKMTCDIRGS 950 LQEDSQVTVA 960 IVLENRSSSI 970 LKGMELSVLD 980 SLNARMARPQ 990 GSSVHDGVPV 1000 PFQLPPGVSN 1010 EAQYVFTIQS 1020 IVMAQKLKGT 1030 LSFIAKNDEG 1040 ATHEKLDFRL 1050 HFSCSSYLIT 1060 TPCYSDAFAK 1070 LLESGDLSMS 1080 SIKVDGIRMS 1090 FQNLLAKICF 1100 HHHFSVVERV 1110 DSCASMYSRS 1120 IQGHHVCLLV 1130 KKGENSVSVD 1140 GKCSDSTLLS 1150 NLLEEMKATL AKC

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0016192	vesicle-mediated transport
Cellular Component	GO:0030123	AP-3 adaptor complex
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0098830	presynaptic endosome
Cellular Component	GO:0043195	terminal bouton
Biological Process	GO:0008089	anterograde axonal transport
Biological Process	GO:0048490	anterograde synaptic vesicle transport
Biological Process	GO:0035654	clathrin-coated vesicle cargo loading, AP-3-mediated
Biological Process	GO:0035646	endosome to melanosome transport
Biological Process	GO:0006896	Golgi to vacuole transport
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:1903232	melanosome assembly
Biological Process	GO:0032438	melanosome organization
Biological Process	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome
Biological Process	GO:0060155	platelet dense granule organization
Biological Process	GO:0072657	protein localization to membrane
Biological Process	GO:0006623	protein targeting to vacuole
Biological Process	GO:0016182	synaptic vesicle budding from endosome
Biological Process	GO:0016183	synaptic vesicle coating
Biological Process	GO:0048499	synaptic vesicle membrane organization
Biological Process	GO:0036465	synaptic vesicle recycling
Biological Process	GO:0140916	zinc ion import into lysosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.