Search Results
Overview
| Uniprot ID | O14618 |
|---|---|
| Protein Name | Copper chaperone for superoxide dismutase |
| Gene Name | CCS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 265 | PIAGKGRKESAQPPA |
Function
Delivers copper to copper zinc superoxide dismutase (SOD1)
Protein Sequence
10
MASDSGNQGT
20
LCTLEFAVQM
30
TCQSCVDAVR
40
KSLQGVAGVQ
50
DVEVHLEDQM
60
VLVHTTLPSQ
70
EVQALLEGTG
80
RQAVLKGMGS
90
GQLQNLGAAV
100
AILGGPGTVQ
110
GVVRFLQLTP
120
ERCLIEGTID
130
GLEPGLHGLH
140
VHQYGDLTNN
150
CNSCGNHFNP
160
DGASHGGPQD
170
SDRHRGDLGN
180
VRADADGRAI
190
FRMEDEQLKV
200
WDVIGRSLII
210
DEGEDDLGRG
220
GHPLSKITGN
230
SGERLACGII
240
ARSAGLFQNP
250
KQICSCDGLT
260
IWEERGRPIA
270
GKGRKESAQP
PAHL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Molecular Function | GO:0016532 | superoxide dismutase copper chaperone activity |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0019430 | removal of superoxide radicals |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.