Search Results

Overview

Uniprot IDO14639
Protein NameActin-binding LIM protein 1
Gene NameABLIM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
345 QSTKTEEKLRPTRTS
549 EDIIKFSKFPAAQAP
652 ASHIPSSKTASLPGY

Function

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance

Protein Sequence

10 MPAFLGLKCL 20 GKLCSSEKSK 30 VTSSERTSAR 40 GSNRKRLIVE 50 DRRVSGTSFT 60 AHRRATITHL 70 LYLCPKDYCP 80 RGRVCNSVDP 90 FVAHPQDPHH 100 PSEKPVIHCH 110 KCGEPCKGEV 120 LRVQTKHFHI 130 KCFTCKVCGC 140 DLAQGGFFIK 150 NGEYLCTLDY 160 QRMYGTRCHG 170 CGEFVEGEVV 180 TALGKTYHPN 190 CFACTICKRP 200 FPPGDRVTFN 210 GRDCLCQLCA 220 QPMSSSPKET 230 TFSSNCAGCG 240 RDIKNGQALL 250 ALDKQWHLGC 260 FKCKSCGKVL 270 TGEYISKDGA 280 PYCEKDYQGL 290 FGVKCEACHQ 300 FITGKVLEAG 310 DKHYHPSCAR 320 CSRCNQMFTE 330 GEEMYLQGST 340 VWHPDCKQST 350 KTEEKLRPTR 360 TSSESIYSRP 370 GSSIPGSPGH 380 TIYAKVDNEI 390 LDYKDLAAIP 400 KVKAIYDIER 410 PDLITYEPFY 420 TSGYDDKQER 430 QSLGESPRTL 440 SPTPSAEGYQ 450 DVRDRMIHRS 460 TSQGSINSPV 470 YSRHSYTPTT 480 SRSPQHFHRP 490 GNEPSSGRNS 500 PLPYRPDSRP 510 LTPTYAQAPK 520 HFHVPDQGIN 530 IYRKPPIYKQ 540 HAALAAQSKS 550 SEDIIKFSKF 560 PAAQAPDPSE 570 TPKIETDHWP 580 GPPSFAVVGP 590 DMKRRSSGRE 600 EDDEELLRRR 610 QLQEEQLMKL 620 NSGLGQLILK 630 EEMEKESRER 640 SSLLASRYDS 650 PINSASHIPS 660 SKTASLPGYG 670 RNGLHRPVST 680 DFAQYNSYGD 690 VSGGVRDYQT 700 LPDGHMPAMR 710 MDRGVSMPNM 720 LEPKIFPYEM 730 LMVTNRGRNK 740 ILREVDRTRL 750 ERHLAPEVFR 760 EIFGMSIQEF 770 DRLPLWRRND MKKKAKLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0060271 cilium assembly
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0007601 visual perception

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.