Search Results

Overview

Uniprot IDO14646
Protein NameATP-dependent chromatin remodeler CHD1
Gene NameCHD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1078 PRMRNCAKQISFNGS
1330 LSGAGSSKRRKARAK
1624 SNLEGSLKDRSHSDH
1653 SSEYTHHKSSRDYRY
401 IIAHSNQKSAAGYPD
88 VDGAEFWKSSPSILA

Function

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity)

Protein Sequence

10 MNGHSDEESV 20 RNSSGESSQS 30 DDDSGSASGS 40 GSGSSSGSSS 50 DGSSSQSGSS 60 DSDSGSESGS 70 QSESESDTSR 80 ENKVQAKPPK 90 VDGAEFWKSS 100 PSILAVQRSA 110 ILKKQQQQQQ 120 QQQHQASSNS 130 GSEEDSSSSE 140 DSDDSSSEVK 150 RKKHKDEDWQ 160 MSGSGSPSQS 170 GSDSESEEER 180 EKSSCDETES 190 DYEPKNKVKS 200 RKPQNRSKSK 210 NGKKILGQKK 220 RQIDSSEEDD 230 DEEDYDNDKR 240 SSRRQATVNV 250 SYKEDEEMKT 260 DSDDLLEVCG 270 EDVPQPEEEE 280 FETIERFMDC 290 RIGRKGATGA 300 TTTIYAVEAD 310 GDPNAGFEKN 320 KEPGEIQYLI 330 KWKGWSHIHN 340 TWETEETLKQ 350 QNVRGMKKLD 360 NYKKKDQETK 370 RWLKNASPED 380 VEYYNCQQEL 390 TDDLHKQYQI 400 VERIIAHSNQ 410 KSAAGYPDYY 420 CKWQGLPYSE 430 CSWEDGALIS 440 KKFQACIDEY 450 FSRNQSKTTP 460 FKDCKVLKQR 470 PRFVALKKQP 480 SYIGGHEGLE 490 LRDYQLNGLN 500 WLAHSWCKGN 510 SCILADEMGL 520 GKTIQTISFL 530 NYLFHEHQLY 540 GPFLLVVPLS 550 TLTSWQREIQ 560 TWASQMNAVV 570 YLGDINSRNM 580 IRTHEWTHHQ 590 TKRLKFNILL 600 TTYEILLKDK 610 AFLGGLNWAF 620 IGVDEAHRLK 630 NDDSLLYKTL 640 IDFKSNHRLL 650 ITGTPLQNSL 660 KELWSLLHFI 670 MPEKFSSWED 680 FEEEHGKGRE 690 YGYASLHKEL 700 EPFLLRRVKK 710 DVEKSLPAKV 720 EQILRMEMSA 730 LQKQYYKWIL 740 TRNYKALSKG 750 SKGSTSGFLN 760 IMMELKKCCN 770 HCYLIKPPDN 780 NEFYNKQEAL 790 QHLIRSSGKL 800 ILLDKLLIRL 810 RERGNRVLIF 820 SQMVRMLDIL 830 AEYLKYRQFP 840 FQRLDGSIKG 850 ELRKQALDHF 860 NAEGSEDFCF 870 LLSTRAGGLG 880 INLASADTVV 890 IFDSDWNPQN 900 DLQAQARAHR 910 IGQKKQVNIY 920 RLVTKGSVEE 930 DILERAKKKM 940 VLDHLVIQRM 950 DTTGKTVLHT 960 GSAPSSSTPF 970 NKEELSAILK 980 FGAEELFKEP 990 EGEEQEPQEM 1000 DIDEILKRAE 1010 THENEPGPLT 1020 VGDELLSQFK 1030 VANFSNMDED 1040 DIELEPERNS 1050 KNWEEIIPED 1060 QRRRLEEEER 1070 QKELEEIYML 1080 PRMRNCAKQI 1090 SFNGSEGRRS 1100 RSRRYSGSDS 1110 DSISEGKRPK 1120 KRGRPRTIPR 1130 ENIKGFSDAE 1140 IRRFIKSYKK 1150 FGGPLERLDA 1160 IARDAELVDK 1170 SETDLRRLGE 1180 LVHNGCIKAL 1190 KDSSSGTERT 1200 GGRLGKVKGP 1210 TFRISGVQVN 1220 AKLVISHEEE 1230 LIPLHKSIPS 1240 DPEERKQYTI 1250 PCHTKAAHFD 1260 IDWGKEDDSN 1270 LLIGIYEYGY 1280 GSWEMIKMDP 1290 DLSLTHKILP 1300 DDPDKKPQAK 1310 QLQTRADYLI 1320 KLLSRDLAKK 1330 EALSGAGSSK 1340 RRKARAKKNK 1350 AMKSIKVKEE 1360 IKSDSSPLPS 1370 EKSDEDDDKL 1380 SESKSDGRER 1390 SKKSSVSDAP 1400 VHITASGEPV 1410 PISEESEELD 1420 QKTFSICKER 1430 MRPVKAALKQ 1440 LDRPEKGLSE 1450 REQLEHTRQC 1460 LIKIGDHITE 1470 CLKEYTNPEQ 1480 IKQWRKNLWI 1490 FVSKFTEFDA 1500 RKLHKLYKHA 1510 IKKRQESQQN 1520 SDQNSNLNPH 1530 VIRNPDVERL 1540 KENTNHDDSS 1550 RDSYSSDRHL 1560 TQYHDHHKDR 1570 HQGDSYKKSD 1580 SRKRPYSSFS 1590 NGKDHRDWDH 1600 YKQDSRYYSD 1610 REKHRKLDDH 1620 RSRDHRSNLE 1630 GSLKDRSHSD 1640 HRSHSDHRLH 1650 SDHRSSSEYT 1660 HHKSSRDYRY 1670 HSDWQMDHRA 1680 SSSGPRSPLD 1690 QRSPYGSRSP 1700 FEHSVEHKST 1710 PEHTWSSRKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140002 histone H3K4me3 reader activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043923 host-mediated activation of viral transcription
Biological Process GO:0034728 nucleosome organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.