Search Results

Overview

Uniprot IDO14647
Protein NameATP-dependent chromatin remodeler CHD2
Gene NameCHD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1629 DNYNHPNKRHFSNAD
1769 YRSFHTDKLGEYKQP

Function

ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity)

Protein Sequence

10 MMRNKDKSQE 20 EDSSLHSNAS 30 SHSASEEASG 40 SDSGSQSESE 50 QGSDPGSGHG 60 SESNSSSESS 70 ESQSESESES 80 AGSKSQPVLP 90 EAKEKPASKK 100 ERIADVKKMW 110 EEYPDVYGVR 120 RSNRSRQEPS 130 RFNIKEEASS 140 GSESGSPKRR 150 GQRQLKKQEK 160 WKQEPSEDEQ 170 EQGTSAESEP 180 EQKKVKARRP 190 VPRRTVPKPR 200 VKKQPKTQRG 210 KRKKQDSSDE 220 DDDDDEAPKR 230 QTRRRAAKNV 240 SYKEDDDFET 250 DSDDLIEMTG 260 EGVDEQQDNS 270 ETIEKVLDSR 280 LGKKGATGAS 290 TTVYAIEANG 300 DPSGDFDTEK 310 DEGEIQYLIK 320 WKGWSYIHST 330 WESEESLQQQ 340 KVKGLKKLEN 350 FKKKEDEIKQ 360 WLGKVSPEDV 370 EYFNCQQELA 380 SELNKQYQIV 390 ERVIAVKTSK 400 STLGQTDFPA 410 HSRKPAPSNE 420 PEYLCKWMGL 430 PYSECSWEDE 440 ALIGKKFQNC 450 IDSFHSRNNS 460 KTIPTRECKA 470 LKQRPRFVAL 480 KKQPAYLGGE 490 NLELRDYQLE 500 GLNWLAHSWC 510 KNNSVILADE 520 MGLGKTIQTI 530 SFLSYLFHQH 540 QLYGPFLIVV 550 PLSTLTSWQR 560 EFEIWAPEIN 570 VVVYIGDLMS 580 RNTIREYEWI 590 HSQTKRLKFN 600 ALITTYEILL 610 KDKTVLGSIN 620 WAFLGVDEAH 630 RLKNDDSLLY 640 KTLIDFKSNH 650 RLLITGTPLQ 660 NSLKELWSLL 670 HFIMPEKFEF 680 WEDFEEDHGK 690 GRENGYQSLH 700 KVLEPFLLRR 710 VKKDVEKSLP 720 AKVEQILRVE 730 MSALQKQYYK 740 WILTRNYKAL 750 AKGTRGSTSG 760 FLNIVMELKK 770 CCNHCYLIKP 780 PEENERENGQ 790 EILLSLIRSS 800 GKLILLDKLL 810 TRLRERGNRV 820 LIFSQMVRML 830 DILAEYLTIK 840 HYPFQRLDGS 850 IKGEIRKQAL 860 DHFNADGSED 870 FCFLLSTRAG 880 GLGINLASAD 890 TVVIFDSDWN 900 PQNDLQAQAR 910 AHRIGQKKQV 920 NIYRLVTKGT 930 VEEEIIERAK 940 KKMVLDHLVI 950 QRMDTTGRTI 960 LENNSGRSNS 970 NPFNKEELTA 980 ILKFGAEDLF 990 KELEGEESEP 1000 QEMDIDEILR 1010 LAETRENEVS 1020 TSATDELLSQ 1030 FKVANFATME 1040 DEEELEERPH 1050 KDWDEIIPEE 1060 QRKKVEEEER 1070 QKELEEIYML 1080 PRIRSSTKKA 1090 QTNDSDSDTE 1100 SKRQAQRSSA 1110 SESETEDSDD 1120 DKKPKRRGRP 1130 RSVRKDLVEG 1140 FTDAEIRRFI 1150 KAYKKFGLPL 1160 ERLECIARDA 1170 ELVDKSVADL 1180 KRLGELIHNS 1190 CVSAMQEYEE 1200 QLKENASEGK 1210 GPGKRRGPTI 1220 KISGVQVNVK 1230 SIIQHEEEFE 1240 MLHKSIPVDP 1250 EEKKKYCLTC 1260 RVKAAHFDVE 1270 WGVEDDSRLL 1280 LGIYEHGYGN 1290 WELIKTDPEL 1300 KLTDKILPVE 1310 TDKKPQGKQL 1320 QTRADYLLKL 1330 LRKGLEKKGA 1340 VTGGEEAKLK 1350 KRKPRVKKEN 1360 KVPRLKEEHG 1370 IELSSPRHSD 1380 NPSEEGEVKD 1390 DGLEKSPMKK 1400 KQKKKENKEN 1410 KEKQMSSRKD 1420 KEGDKERKKS 1430 KDKKEKPKSG 1440 DAKSSSKSKR 1450 SQGPVHITAG 1460 SEPVPIGEDE 1470 DDDLDQETFS 1480 ICKERMRPVK 1490 KALKQLDKPD 1500 KGLNVQEQLE 1510 HTRNCLLKIG 1520 DRIAECLKAY 1530 SDQEHIKLWR 1540 RNLWIFVSKF 1550 TEFDARKLHK 1560 LYKMAHKKRS 1570 QEEEEQKKKD 1580 DVTGGKKPFR 1590 PEASGSSRDS 1600 LISQSHTSHN 1610 LHPQKPHLPA 1620 SHGPQMHGHP 1630 RDNYNHPNKR 1640 HFSNADRGDW 1650 QRERKFNYGG 1660 GNNNPPWGSD 1670 RHHQYEQHWY 1680 KDHHYGDRRH 1690 MDAHRSGSYR 1700 PNNMSRKRPY 1710 DQYSSDRDHR 1720 GHRDYYDRHH 1730 HDSKRRRSDE 1740 FRPQNYHQQD 1750 FRRMSDHRPA 1760 MGYHGQGPSD 1770 HYRSFHTDKL 1780 GEYKQPLPPL 1790 HPAVSDPRSP 1800 PSQKSPHDSK 1810 SPLDHRSPLE 1820 RSLEQKNNPD YNWNVRKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007517 muscle organ development
Biological Process GO:0034728 nucleosome organization

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.