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Overview

Uniprot IDO14654
Protein NameInsulin receptor substrate 4
Gene NameIRS4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
618 KKRSYFGKLTQSKQQ

Function

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2

Protein Sequence

10 MASCSFTRDQ 20 ATRRLRGAAA 30 AAAAALAAVV 40 TTPLLSSGTP 50 TALIGTGSSC 60 PGAMWLSTAT 70 GSRSDSESEE 80 EDLPVGEEVC 90 KRGYLRKQKH 100 GHRRYFVLKL 110 ETADAPARLE 120 YYENARKFRH 130 SVRAAAAAAA 140 AAASGAAIPP 150 LIPPRRVITL 160 YQCFSVSQRA 170 DARYRHLIAL 180 FTQDEYFAMV 190 AENESEQESW 200 YLLLSRLILE 210 SKRRRCGTLG 220 AQPDGEPAAL 230 AAAAAAEPPF 240 YKDVWQVIVK 250 PRGLGHRKEL 260 SGVFRLCLTD 270 EEVVFVRLNT 280 EVASVVVQLL 290 SIRRCGHSEQ 300 YFFLEVGRST 310 VIGPGELWMQ 320 VDDCVVAQNM 330 HELFLEKMRA 340 LCADEYRARC 350 RSYSISIGAH 360 LLTLLSARRH 370 LGLVPLEPGG 380 WLRRSRFEQF 390 CHLRAIGDGE 400 DEMLFTRRFV 410 TPSEPVAHSR 420 RGRLHLPRGR 430 RSRRAVSVPA 440 SFFRRLAPSP 450 ARPRHPAEAP 460 NNGARLSSEV 470 SGSGSGNFGE 480 EGNPQGKEDQ 490 EGSGGDYMPM 500 NNWGSGNGRG 510 SGGGQGSNGQ 520 GSSSHSSGGN 530 QCSGEGQGSR 540 GGQGSNGQGS 550 GGNQCSRDGQ 560 GTAGGHGSGG 570 GQRPGGGHGS 580 GGGQGPGDGH 590 GSGGGKNSGG 600 GKGSGSGKGS 610 DGDGERGKSL 620 KKRSYFGKLT 630 QSKQQQMPPP 640 PPPPPPPPPA 650 GGTGGKGKSG 660 GRFRLYFCVD 670 RGATKECKEA 680 KEVKDAEIPE 690 GAARGPHRAR 700 AFDEDEDDPY 710 VPMRPGVATP 720 LVSSSDYMPM 730 APQNVSASKK 740 RHSRSPFEDS 750 RGYMMMFPRV 760 SPPPAPSPPK 770 APDTNKEDDS 780 KDNDSESDYM 790 FMAPGAGAIP 800 KNPRNPQGGS 810 SSKSWSSYFS 820 LPNPFRSSPL 830 GQNDNSEYVP 840 MLPGKFLGRG 850 LDKEVSYNWD 860 PKDAASKPSG 870 EGSFSKPGDG 880 GSPSKPSDHE 890 PPKNKAKRPN 900 RLSFITKGYK 910 IKPKPQKPTH 920 EQREADSSSD 930 YVNMDFTKRE 940 SNTPAPSTQG 950 LPDSWGIIAE 960 PRQSAFSNYV 970 NVEFGVPFPN 980 PANDLSDLLR 990 AIPRANPLSL 1000 DSARWPLPPL 1010 PLSATGSNAI 1020 EEEGDYIEVI 1030 FNSAMTPAMA 1040 LADSAIRYDA 1050 ETGRIYVVDP 1060 FSECCMDISL 1070 SPSRCSEPPP 1080 VARLLQEEEQ 1090 ERRRPQSRSQ 1100 SFFAAARAAV 1110 SAFPTDSLER 1120 DLSPSSAPAV 1130 ASAAEPTLAL 1140 SQVVAAASAL 1150 AAAPGIGAAA 1160 AAAGFDSASA 1170 RWFQPVANAA 1180 DAEAVRGAQD 1190 VAGGSNPGAH 1200 NPSANLARGD 1210 NQAGGAAAAA 1220 AAPEPPPRSR 1230 RVPRPPERED 1240 SDNDDDTHVR 1250 MDFARRDNQF DSPKRGR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0007165 signal transduction

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.