Search Results

Overview

Uniprot IDO14686
Protein NameHistone-lysine N-methyltransferase 2D
Gene NameKMT2D
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1763 RRGRKKSKLEDMFPA

Function

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732)

Protein Sequence

10 MDSQKLAGED 20 KDSEPAADGP 30 AASEDPSATE 40 SDLPNPHVGE 50 VSVLSSGSPR 60 LQETPQDCSG 70 GPVRRCALCN 80 CGEPSLHGQR 90 ELRRFELPFD 100 WPRCPVVSPG 110 GSPGPNEAVL 120 PSEDLSQIGF 130 PEGLTPAHLG 140 EPGGSCWAHH 150 WCAAWSAGVW 160 GQEGPELCGV 170 DKAIFSGISQ 180 RCSHCTRLGA 190 SIPCRSPGCP 200 RLYHFPCATA 210 SGSFLSMKTL 220 QLLCPEHSEG 230 AAYLEEARCA 240 VCEGPGELCD 250 LFFCTSCGHH 260 YHGACLDTAL 270 TARKRAGWQC 280 PECKVCQACR 290 KPGNDSKMLV 300 CETCDKGYHT 310 FCLKPPMEEL 320 PAHSWKCKAC 330 RVCRACGAGS 340 AELNPNSEWF 350 ENYSLCHRCH 360 KAQGGQTIRS 370 VAEQHTPVCS 380 RFSPPEPGDT 390 PTDEPDALYV 400 ACQGQPKGGH 410 VTSMQPKEPG 420 PLQCEAKPLG 430 KAGVQLEPQL 440 EAPLNEEMPL 450 LPPPEESPLS 460 PPPEESPTSP 470 PPEASRLSPP 480 PEELPASPLP 490 EALHLSRPLE 500 ESPLSPPPEE 510 SPLSPPPESS 520 PFSPLEESPL 530 SPPEESPPSP 540 ALETPLSPPP 550 EASPLSPPFE 560 ESPLSPPPEE 570 LPTSPPPEAS 580 RLSPPPEESP 590 MSPPPEESPM 600 SPPPEASRLF 610 PPFEESPLSP 620 PPEESPLSPP 630 PEASRLSPPP 640 EDSPMSPPPE 650 ESPMSPPPEV 660 SRLSPLPVVS 670 RLSPPPEESP 680 LSPPPEESPT 690 SPPPEASRLS 700 PPPEDSPTSP 710 PPEDSPASPP 720 PEDSLMSLPL 730 EESPLLPLPE 740 EPQLCPRSEG 750 PHLSPRPEEP 760 HLSPRPEEPH 770 LSPQAEEPHL 780 SPQPEEPCLC 790 AVPEEPHLSP 800 QAEGPHLSPQ 810 PEELHLSPQT 820 EEPHLSPVPE 830 EPCLSPQPEE 840 SHLSPQSEEP 850 CLSPRPEESH 860 LSPELEKPPL 870 SPRPEKPPEE 880 PGQCPAPEEL 890 PLFPPPGEPS 900 LSPLLGEPAL 910 SEPGEPPLSP 920 LPEELPLSPS 930 GEPSLSPQLM 940 PPDPLPPPLS 950 PIITAAAPPA 960 LSPLGELEYP 970 FGAKGDSDPE 980 SPLAAPILET 990 PISPPPEANC 1000 TDPEPVPPMI 1010 LPPSPGSPVG 1020 PASPILMEPL 1030 PPQCSPLLQH 1040 SLVPQNSPPS 1050 QCSPPALPLS 1060 VPSPLSPIGK 1070 VVGVSDEAEL 1080 HEMETEKVSE 1090 PECPALEPSA 1100 TSPLPSPMGD 1110 LSCPAPSPAP 1120 ALDDFSGLGE 1130 DTAPLDGIDA 1140 PGSQPEPGQT 1150 PGSLASELKG 1160 SPVLLDPEEL 1170 APVTPMEVYP 1180 ECKQTAGQGS 1190 PCEEQEEPRA 1200 PVAPTPPTLI 1210 KSDIVNEISN 1220 LSQGDASASF 1230 PGSEPLLGSP 1240 DPEGGGSLSM 1250 ELGVSTDVSP 1260 ARDEGSLRLC 1270 TDSLPETDDS 1280 LLCDAGTAIS 1290 GGKAEGEKGR 1300 RRSSPARSRI 1310 KQGRSSSFPG 1320 RRRPRGGAHG 1330 GRGRGRARLK 1340 STASSIETLV 1350 VADIDSSPSK 1360 EEEEEDDDTM 1370 QNTVVLFSNT 1380 DKFVLMQDMC 1390 VVCGSFGRGA 1400 EGHLLACSQC 1410 SQCYHPYCVN 1420 SKITKVMLLK 1430 GWRCVECIVC 1440 EVCGQASDPS 1450 RLLLCDDCDI 1460 SYHTYCLDPP 1470 LLTVPKGGWK 1480 CKWCVSCMQC 1490 GAASPGFHCE 1500 WQNSYTHCGP 1510 CASLVTCPIC 1520 HAPYVEEDLL 1530 IQCRHCERWM 1540 HAGCESLFTE 1550 DDVEQAADEG 1560 FDCVSCQPYV 1570 VKPVAPVAPP 1580 ELVPMKVKEP 1590 EPQYFRFEGV 1600 WLTETGMALL 1610 RNLTMSPLHK 1620 RRQRRGRLGL 1630 PGEAGLEGSE 1640 PSDALGPDDK 1650 KDGDLDTDEL 1660 LKGEGGVEHM 1670 ECEIKLEGPV 1680 SPDVEPGKEE 1690 TEESKKRKRK 1700 PYRPGIGGFM 1710 VRQRKSHTRT 1720 KKGPAAQAEV 1730 LSGDGQPDEV 1740 IPADLPAEGA 1750 VEQSLAEGDE 1760 KKKQQRRGRK 1770 KSKLEDMFPA 1780 YLQEAFFGKE 1790 LLDLSRKALF 1800 AVGVGRPSFG 1810 LGTPKAKGDG 1820 GSERKELPTS 1830 QKGDDGPDIA 1840 DEESRGLEGK 1850 ADTPGPEDGG 1860 VKASPVPSDP 1870 EKPGTPGEGM 1880 LSSDLDRIST 1890 EELPKMESKD 1900 LQQLFKDVLG 1910 SEREQHLGCG 1920 TPGLEGSRTP 1930 LQRPFLQGGL 1940 PLGNLPSSSP 1950 MDSYPGLCQS 1960 PFLDSRERGG 1970 FFSPEPGEPD 1980 SPWTGSGGTT 1990 PSTPTTPTTE 2000 GEGDGLSYNQ 2010 RSLQRWEKDE 2020 ELGQLSTISP 2030 VLYANINFPN 2040 LKQDYPDWSS 2050 RCKQIMKLWR 2060 KVPAADKAPY 2070 LQKAKDNRAA 2080 HRINKVQKQA 2090 ESQINKQTKV 2100 GDIARKTDRP 2110 ALHLRIPPQP 2120 GALGSPPPAA 2130 APTIFIGSPT 2140 TPAGLSTSAD 2150 GFLKPPAGSV 2160 PGPDSPGELF 2170 LKLPPQVPAQ 2180 VPSQDPFGLA 2190 PAYPLEPRFP 2200 TAPPTYPPYP 2210 SPTGAPAQPP 2220 MLGASSRPGA 2230 GQPGEFHTTP 2240 PGTPRHQPST 2250 PDPFLKPRCP 2260 SLDNLAVPES 2270 PGVGGGKASE 2280 PLLSPPPFGE 2290 SRKALEVKKE 2300 ELGASSPSYG 2310 PPNLGFVDSP 2320 SSGTHLGGLE 2330 LKTPDVFKAP 2340 LTPRASQVEP 2350 QSPGLGLRPQ 2360 EPPPAQALAP 2370 SPPSHPDIFR 2380 PGSYTDPYAQ 2390 PPLTPRPQPP 2400 PPESCCALPP 2410 RSLPSDPFSR 2420 VPASPQSQSS 2430 SQSPLTPRPL 2440 SAEAFCPSPV 2450 TPRFQSPDPY 2460 SRPPSRPQSR 2470 DPFAPLHKPP 2480 RPQPPEVAFK 2490 AGSLAHTSLG 2500 AGGFPAALPA 2510 GPAGELHAKV 2520 PSGQPPNFVR 2530 SPGTGAFVGT 2540 PSPMRFTFPQ 2550 AVGEPSLKPP 2560 VPQPGLPPPH 2570 GINSHFGPGP 2580 TLGKPQSTNY 2590 TVATGNFHPS 2600 GSPLGPSSGS 2610 TGESYGLSPL 2620 RPPSVLPPPA 2630 PDGSLPYLSH 2640 GASQRSGITS 2650 PVEKREDPGT 2660 GMGSSLATAE 2670 LPGTQDPGMS 2680 GLSQTELEKQ 2690 RQRQRLRELL 2700 IRQQIQRNTL 2710 RQEKETAAAA 2720 AGAVGPPGSW 2730 GAEPSSPAFE 2740 QLSRGQTPFA 2750 GTQDKSSLVG 2760 LPPSKLSGPI 2770 LGPGSFPSDD 2780 RLSRPPPPAT 2790 PSSMDVNSRQ 2800 LVGGSQAFYQ 2810 RAPYPGSLPL 2820 QQQQQQLWQQ 2830 QQATAATSMR 2840 FAMSARFPST 2850 PGPELGRQAL 2860 GSPLAGISTR 2870 LPGPGEPVPG 2880 PAGPAQFIEL 2890 RHNVQKGLGP 2900 GGTPFPGQGP 2910 PQRPRFYPVS 2920 EDPHRLAPEG 2930 LRGLAVSGLP 2940 PQKPSAPPAP 2950 ELNNSLHPTP 2960 HTKGPTLPTG 2970 LELVNRPPSS 2980 TELGRPNPLA 2990 LEAGKLPCED 3000 PELDDDFDAH 3010 KALEDDEELA 3020 HLGLGVDVAK 3030 GDDELGTLEN 3040 LETNDPHLDD 3050 LLNGDEFDLL 3060 AYTDPELDTG 3070 DKKDIFNEHL 3080 RLVESANEKA 3090 EREALLRGVE 3100 PGPLGPEERP 3110 PPAADASEPR 3120 LASVLPEVKP 3130 KVEEGGRHPS 3140 PCQFTIATPK 3150 VEPAPAANSL 3160 GLGLKPGQSM 3170 MGSRDTRMGT 3180 GPFSSSGHTA 3190 EKASFGATGG 3200 PPAHLLTPSP 3210 LSGPGGSSLL 3220 EKFELESGAL 3230 TLPGGPAASG 3240 DELDKMESSL 3250 VASELPLLIE 3260 DLLEHEKKEL 3270 QKKQQLSAQL 3280 QPAQQQQQQQ 3290 QQHSLLSAPG 3300 PAQAMSLPHE 3310 GSSPSLAGSQ 3320 QQLSLGLAGA 3330 RQPGLPQPLM 3340 PTQPPAHALQ 3350 QRLAPSMAMV 3360 SNQGHMLSGQ 3370 HGGQAGLVPQ 3380 QSSQPVLSQK 3390 PMGTMPPSMC 3400 MKPQQLAMQQ 3410 QLANSFFPDT 3420 DLDKFAAEDI 3430 IDPIAKAKMV 3440 ALKGIKKVMA 3450 QGSIGVAPGM 3460 NRQQVSLLAQ 3470 RLSGGPSSDL 3480 QNHVAAGSGQ 3490 ERSAGDPSQP 3500 RPNPPTFAQG 3510 VINEADQRQY 3520 EEWLFHTQQL 3530 LQMQLKVLEE 3540 QIGVHRKSRK 3550 ALCAKQRTAK 3560 KAGREFPEAD 3570 AEKLKLVTEQ 3580 QSKIQKQLDQ 3590 VRKQQKEHTN 3600 LMAEYRNKQQ 3610 QQQQQQQQQQ 3620 QQHSAVLALS 3630 PSQSPRLLTK 3640 LPGQLLPGHG 3650 LQPPQGPPGG 3660 QAGGLRLTPG 3670 GMALPGQPGG 3680 PFLNTALAQQ 3690 QQQQHSGGAG 3700 SLAGPSGGFF 3710 PGNLALRSLG 3720 PDSRLLQERQ 3730 LQLQQQRMQL 3740 AQKLQQQQQQ 3750 QQQQQHLLGQ 3760 VAIQQQQQQG 3770 PGVQTNQALG 3780 PKPQGLMPPS 3790 SHQGLLVQQL 3800 SPQPPQGPQG 3810 MLGPAQVAVL 3820 QQQHPGALGP 3830 QGPHRQVLMT 3840 QSRVLSSPQL 3850 AQQGQGLMGH 3860 RLVTAQQQQQ 3870 QQQHQQQGSM 3880 AGLSHLQQSL 3890 MSHSGQPKLS 3900 AQPMGSLQQL 3910 QQQQQLQQQQ 3920 QLQQQQQQQL 3930 QQQQQLQQQQ 3940 LQQQQQQQQL 3950 QQQQQQQLQQ 3960 QQQQLQQQQQ 3970 QQQQQFQQQQ 3980 QQQQMGLLNQ 3990 SRTLLSPQQQ 4000 QQQQVALGPG 4010 MPAKPLQHFS 4020 SPGALGPTLL 4030 LTGKEQNTVD 4040 PAVSSEATEG 4050 PSTHQGGPLA 4060 IGTTPESMAT 4070 EPGEVKPSLS 4080 GDSQLLLVQP 4090 QPQPQPSSLQ 4100 LQPPLRLPGQ 4110 QQQQVSLLHT 4120 AGGGSHGQLG 4130 SGSSSEASSV 4140 PHLLAQPSVS 4150 LGDQPGSMTQ 4160 NLLGPQQPML 4170 ERPMQNNTGP 4180 QPPKPGPVLQ 4190 SGQGLPGVGI 4200 MPTVGQLRAQ 4210 LQGVLAKNPQ 4220 LRHLSPQQQQ 4230 QLQALLMQRQ 4240 LQQSQAVRQT 4250 PPYQEPGTQT 4260 SPLQGLLGCQ 4270 PQLGGFPGPQ 4280 TGPLQELGAG 4290 PRPQGPPRLP 4300 APPGALSTGP 4310 VLGPVHPTPP 4320 PSSPQEPKRP 4330 SQLPSPSSQL 4340 PTEAQLPPTH 4350 PGTPKPQGPT 4360 LEPPPGRVSP 4370 AAAQLADTLF 4380 SKGLGPWDPP 4390 DNLAETQKPE 4400 QSSLVPGHLD 4410 QVNGQVVPEA 4420 SQLSIKQEPR 4430 EEPCALGAQS 4440 VKREANGEPI 4450 GAPGTSNHLL 4460 LAGPRSEAGH 4470 LLLQKLLRAK 4480 NVQLSTGRGS 4490 EGLRAEINGH 4500 IDSKLAGLEQ 4510 KLQGTPSNKE 4520 DAAARKPLTP 4530 KPKRVQKASD 4540 RLVSSRKKLR 4550 KEDGVRASEA 4560 LLKQLKQELS 4570 LLPLTEPAIT 4580 ANFSLFAPFG 4590 SGCPVNGQSQ 4600 LRGAFGSGAL 4610 PTGPDYYSQL 4620 LTKNNLSNPP 4630 TPPSSLPPTP 4640 PPSVQQKMVN 4650 GVTPSEELGE 4660 HPKDAASARD 4670 SERALRDTSE 4680 VKSLDLLAAL 4690 PTPPHNQTED 4700 VRMESDEDSD 4710 SPDSIVPASS 4720 PESILGEEAP 4730 RFPHLGSGRW 4740 EQEDRALSPV 4750 IPLIPRASIP 4760 VFPDTKPYGA 4770 LGLEVPGKLP 4780 VTTWEKGKGS 4790 EVSVMLTVSA 4800 AAAKNLNGVM 4810 VAVAELLSMK 4820 IPNSYEVLFP 4830 ESPARAGTEP 4840 KKGEAEGPGG 4850 KEKGLEGKSP 4860 DTGPDWLKQF 4870 DAVLPGYTLK 4880 SQLDILSLLK 4890 QESPAPEPPT 4900 QHSYTYNVSN 4910 LDVRQLSAPP 4920 PEEPSPPPSP 4930 LAPSPASPPT 4940 EPLVELPTEP 4950 LAEPPVPSPL 4960 PLASSPESAR 4970 PKPRARPPEE 4980 GEDSRPPRLK 4990 KWKGVRWKRL 5000 RLLLTIQKGS 5010 GRQEDEREVA 5020 EFMEQLGTAL 5030 RPDKVPRDMR 5040 RCCFCHEEGD 5050 GATDGPARLL 5060 NLDLDLWVHL 5070 NCALWSTEVY 5080 ETQGGALMNV 5090 EVALHRGLLT 5100 KCSLCQRTGA 5110 TSSCNRMRCP 5120 NVYHFACAIR 5130 AKCMFFKDKT 5140 MLCPMHKIKG 5150 PCEQELSSFA 5160 VFRRVYIERD 5170 EVKQIASIIQ 5180 RGERLHMFRV 5190 GGLVFHAIGQ 5200 LLPHQMADFH 5210 SATALYPVGY 5220 EATRIYWSLR 5230 TNNRRCCYRC 5240 SIGENNGRPE 5250 FVIKVIEQGL 5260 EDLVFTDASP 5270 QAVWNRIIEP 5280 VAAMRKEADM 5290 LRLFPEYLKG 5300 EELFGLTVHA 5310 VLRIAESLPG 5320 VESCQNYLFR 5330 YGRHPLMELP 5340 LMINPTGCAR 5350 SEPKILTHYK 5360 RPHTLNSTSM 5370 SKAYQSTFTG 5380 ETNTPYSKQF 5390 VHSKSSQYRR 5400 LRTEWKNNVY 5410 LARSRIQGLG 5420 LYAAKDLEKH 5430 TMVIEYIGTI 5440 IRNEVANRRE 5450 KIYEEQNRGI 5460 YMFRINNEHV 5470 IDATLTGGPA 5480 RYINHSCAPN 5490 CVAEVVTFDK 5500 EDKIIIISSR 5510 RIPKGEELTY 5520 DYQFDFEDDQ 5530 HKIPCHCGAW NCRKWMN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044666 MLL3/4 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042800 histone H3K4 methyltransferase activity
Molecular Function GO:0140945 histone H3K4 monomethyltransferase activity
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:1904837 beta-catenin-TCF complex assembly
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0032259 methylation
Biological Process GO:0001555 oocyte growth
Biological Process GO:0048477 oogenesis
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0043627 response to estrogen

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.