Overview
| Uniprot ID | O14733 |
|---|
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 7 |
|---|
| Gene Name | MAP2K7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 9 |
AASSLEQKLSRLEAK |
Function
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074)
Protein Sequence
10
MAASSLEQKL
20
SRLEAKLKQE
30
NREARRRIDL
40
NLDISPQRPR
50
PTLQLPLAND
60
GGSRSPSSES
70
SPQHPTPPAR
80
PRHMLGLPST
90
LFTPRSMESI
100
EIDQKLQEIM
110
KQTGYLTIGG
120
QRYQAEINDL
130
ENLGEMGSGT
140
CGQVWKMRFR
150
KTGHVIAVKQ
160
MRRSGNKEEN
170
KRILMDLDVV
180
LKSHDCPYIV
190
QCFGTFITNT
200
DVFIAMELMG
210
TCAEKLKKRM
220
QGPIPERILG
230
KMTVAIVKAL
240
YYLKEKHGVI
250
HRDVKPSNIL
260
LDERGQIKLC
270
DFGISGRLVD
280
SKAKTRSAGC
290
AAYMAPERID
300
PPDPTKPDYD
310
IRADVWSLGI
320
SLVELATGQF
330
PYKNCKTDFE
340
VLTKVLQEEP
350
PLLPGHMGFS
360
GDFQSFVKDC
370
LTKDHRKRPK
380
YNKLLEHSFI
390
KRYETLEVDV
400
ASWFKDVMAK
410
TESPRTSGVL
SQPHLPFFR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0008545 |
JUN kinase kinase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0004707 |
MAP kinase activity |
| Molecular Function |
GO:0004708 |
MAP kinase kinase activity |
| Molecular Function |
GO:0140677 |
molecular function activator activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004713 |
protein tyrosine kinase activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0071347 |
cellular response to interleukin-1 |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0090398 |
cellular senescence |
| Biological Process |
GO:0038095 |
Fc-epsilon receptor signaling pathway |
| Biological Process |
GO:0007254 |
JNK cascade |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0046330 |
positive regulation of JNK cascade |
| Biological Process |
GO:0032206 |
positive regulation of telomere maintenance |
| Biological Process |
GO:0009408 |
response to heat |
| Biological Process |
GO:0006970 |
response to osmotic stress |
| Biological Process |
GO:0034612 |
response to tumor necrosis factor |
| Biological Process |
GO:0009411 |
response to UV |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0051403 |
stress-activated MAPK cascade |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.