Search Results
Overview
| Uniprot ID | O14737 |
|---|---|
| Protein Name | Programmed cell death protein 5 |
| Gene Name | PDCD5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | KVSQQTEKTTTVKFN |
| 110 | TEKTTTVKFNRRKVM |
| 115 | TVKFNRRKVMDSDED |
| 20 | RLAELQAKHGDPGDA |
| 33 | DAAQQEAKHREAEMR |
| 63 | LSNLALVKPEKTKAV |
| 66 | LALVKPEKTKAVENY |
Function
In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:19616514, PubMed:22914926, PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (PubMed:19308289)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0010698 | acetyltransferase activator activity |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008201 | heparin binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:1903333 | negative regulation of protein folding |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0042981 | regulation of apoptotic process |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.