Search Results
Overview
| Uniprot ID | O14745 |
|---|---|
| Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| Gene Name | NHERF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | GFNLHSDKSKPGQFI |
| 32 | GFHLHGEKGKLGQYI |
| 34 | HLHGEKGKLGQYIRL |
| 50 | EPGSPAEKAGLLAGD |
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Biological Process | GO:0045930 | negative regulation of mitotic cell cycle |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0007097 | nuclear migration |
| Biological Process | GO:0007009 | plasma membrane organization |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0008361 | regulation of cell size |
| Biological Process | GO:0045859 | regulation of protein kinase activity |
| Biological Process | GO:0070293 | renal absorption |
| Biological Process | GO:0097291 | renal phosphate ion absorption |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Biological Process | GO:0016055 | Wnt signaling pathway |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0031526 | brush border membrane |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0031528 | microvillus membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098797 | plasma membrane protein complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0032426 | stereocilium tip |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0031698 | beta-2 adrenergic receptor binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0099103 | channel activator activity |
| Molecular Function | GO:0017081 | chloride channel regulator activity |
| Molecular Function | GO:0050780 | dopamine receptor binding |
| Molecular Function | GO:0070851 | growth factor receptor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0031799 | type 2 metabotropic glutamate receptor binding |
| Molecular Function | GO:0031800 | type 3 metabotropic glutamate receptor binding |
| Biological Process | GO:0032782 | bile acid secretion |
| Biological Process | GO:0090660 | cerebrospinal fluid circulation |
| Biological Process | GO:0044782 | cilium organization |
| Biological Process | GO:0045198 | establishment of epithelial cell apical/basal polarity |
| Biological Process | GO:0051683 | establishment of Golgi localization |
| Biological Process | GO:0051939 | gamma-aminobutyric acid import |
| Biological Process | GO:0022612 | gland morphogenesis |
| Biological Process | GO:0034635 | glutathione transport |
| Biological Process | GO:0098739 | import across plasma membrane |
| Biological Process | GO:0045199 | maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0030033 | microvillus assembly |
| Biological Process | GO:0002009 | morphogenesis of an epithelium |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:2000146 | negative regulation of cell motility |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.