Overview
| Uniprot ID | O14756 |
|---|
| Protein Name | 17-beta-hydroxysteroid dehydrogenase type 6 |
|---|
| Gene Name | HSD17B6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 228 |
ERMKQSWKEAPKHIK |
| 98 |
AAATQWVKEHVGDRG |
Function
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids
Protein Sequence
10
MWLYLAAFVG
20
LYYLLHWYRE
30
RQVVSHLQDK
40
YVFITGCDSG
50
FGNLLARQLD
60
ARGLRVLAAC
70
LTEKGAEQLR
80
GQTSDRLETV
90
TLDVTKMESI
100
AAATQWVKEH
110
VGDRGLWGLV
120
NNAGILTPIT
130
LCEWLNTEDS
140
MNMLKVNLIG
150
VIQVTLSMLP
160
LVRRARGRIV
170
NVSSILGRVA
180
FFVGGYCVSK
190
YGVEAFSDIL
200
RREIQHFGVK
210
ISIVEPGYFR
220
TGMTNMTQSL
230
ERMKQSWKEA
240
PKHIKETYGQ
250
QYFDALYNIM
260
KEGLLNCSTN
270
LNLVTDCMEH
280
ALTSVHPRTR
290
YSAGWDAKFF
300
FIPLSYLPTS
310
LADYILTRSW
PKPAQAV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Molecular Function |
GO:0047024 |
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0004745 |
all-trans-retinol dehydrogenase (NAD+) activity |
| Molecular Function |
GO:0047044 |
androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity |
| Molecular Function |
GO:0047023 |
androsterone dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0003824 |
catalytic activity |
| Molecular Function |
GO:0009055 |
electron transfer activity |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0047035 |
testosterone dehydrogenase (NAD+) activity |
| Molecular Function |
GO:0047045 |
testosterone dehydrogenase (NADP+) activity |
| Biological Process |
GO:0006702 |
androgen biosynthetic process |
| Biological Process |
GO:0006710 |
androgen catabolic process |
| Biological Process |
GO:0062175 |
brexanolone catabolic process |
| Biological Process |
GO:0006703 |
estrogen biosynthetic process |
| Biological Process |
GO:0042572 |
retinol metabolic process |
| Biological Process |
GO:0008202 |
steroid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.