Search Results

Overview

Uniprot IDO14776
Protein NameTranscription elongation regulator 1
Gene NameTCERG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1011 FEEYIRDKYITAKAD

Function

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter

Protein Sequence

10 MAERGGDGGE 20 SERFNPGELR 30 MAQQQALRFR 40 GPAPPPNAVM 50 RGPPPLMRPP 60 PPFGMMRGPP 70 PPPRPPFGRP 80 PFDPNMPPMP 90 PPGGIPPPMG 100 PPHLQRPPFM 110 PPPMSSMPPP 120 PGMMFPPGMP 130 PVTAPGTPAL 140 PPTEEIWVEN 150 KTPDGKVYYY 160 NARTRESAWT 170 KPDGVKVIQQ 180 SELTPMLAAQ 190 AQVQAQAQAQ 200 AQAQAQAQAQ 210 AQAQAQAQAQ 220 AQAQAQAQAQ 230 AQAQAQAQAQ 240 AQAQAQAQAQ 250 AQVQAQVQAQ 260 VQAQAVGAST 270 PTTSSPAPAV 280 STSTSSSTPS 290 STTSTTTTAT 300 SVAQTVSTPT 310 TQDQTPSSAV 320 SVATPTVSVS 330 TPAPTATPVQ 340 TVPQPHPQTL 350 PPAVPHSVPQ 360 PTTAIPAFPP 370 VMVPPFRVPL 380 PGMPIPLPGV 390 AMMQIVSCPY 400 VKTVATTKTG 410 VLPGMAPPIV 420 PMIHPQVAIA 430 ASPATLAGAT 440 AVSEWTEYKT 450 ADGKTYYYNN 460 RTLESTWEKP 470 QELKEKEKLE 480 EKIKEPIKEP 490 SEEPLPMETE 500 EEDPKEEPIK 510 EIKEEPKEEE 520 MTEEEKAAQK 530 AKPVATAPIP 540 GTPWCVVWTG 550 DERVFFYNPT 560 TRLSMWDRPD 570 DLIGRADVDK 580 IIQEPPHKKG 590 MEELKKLRHP 600 TPTMLSIQKW 610 QFSMSAIKEE 620 QELMEEINED 630 EPVKAKKRKR 640 DDNKDIDSEK 650 EAAMEAEIKA 660 ARERAIVPLE 670 ARMKQFKDML 680 LERGVSAFST 690 WEKELHKIVF 700 DPRYLLLNPK 710 ERKQVFDQYV 720 KTRAEEERRE 730 KKNKIMQAKE 740 DFKKMMEEAK 750 FNPRATFSEF 760 AAKHAKDSRF 770 KAIEKMKDRE 780 ALFNEFVAAA 790 RKKEKEDSKT 800 RGEKIKSDFF 810 ELLSNHHLDS 820 QSRWSKVKDK 830 VESDPRYKAV 840 DSSSMREDLF 850 KQYIEKIAKN 860 LDSEKEKELE 870 RQARIEASLR 880 EREREVQKAR 890 SEQTKEIDRE 900 REQHKREEAI 910 QNFKALLSDM 920 VRSSDVSWSD 930 TRRTLRKDHR 940 WESGSLLERE 950 EKEKLFNEHI 960 EALTKKKREH 970 FRQLLDETSA 980 ITLTSTWKEV 990 KKIIKEDPRC 1000 IKFSSSDRKK 1010 QREFEEYIRD 1020 KYITAKADFR 1030 TLLKETKFIT 1040 YRSKKLIQES 1050 DQHLKDVEKI 1060 LQNDKRYLVL 1070 DCVPEERRKL 1080 IVAYVDDLDR 1090 RGPPPPPTAS EPTRRSTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0070063 RNA polymerase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0003711 transcription elongation factor activity
Molecular Function GO:0044390 ubiquitin-like protein conjugating enzyme binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0034244 negative regulation of transcription elongation by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0008380 RNA splicing

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.