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Overview

Uniprot IDO14787
Protein NameTransportin-2
Gene NameTNPO2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
762 INRPNTPKTLLENTG

Function

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)

Protein Sequence

10 MDWQPDEQGL 20 QQVLQLLKDS 30 QSPNTATQRI 40 VQDKLKQLNQ 50 FPDFNNYLIF 60 VLTRLKSEDE 70 PTRSLSGLIL 80 KNNVKAHYQS 90 FPPPVADFIK 100 QECLNNIGDA 110 SSLIRATIGI 120 LITTIASKGE 130 LQMWPELLPQ 140 LCNLLNSEDY 150 NTCEGAFGAL 160 QKICEDSSEL 170 LDSDALNRPL 180 NIMIPKFLQF 190 FKHCSPKIRS 200 HAIACVNQFI 210 MDRAQALMDN 220 IDTFIEHLFA 230 LAVDDDPEVR 240 KNVCRALVML 250 LEVRIDRLIP 260 HMHSIIQYML 270 QRTQDHDENV 280 ALEACEFWLT 290 LAEQPICKEV 300 LASHLVQLIP 310 ILVNGMKYSE 320 IDIILLKGDV 330 EEDEAVPDSE 340 QDIKPRFHKS 350 RTVTLPHEAE 360 RPDGSEDAED 370 DDDDDALSDW 380 NLRKCSAAAL 390 DVLANVFREE 400 LLPHLLPLLK 410 GLLFHPEWVV 420 KESGILVLGA 430 IAEGCMQGMV 440 PYLPELIPHL 450 IQCLSDKKAL 460 VRSIACWTLS 470 RYAHWVVSQP 480 PDMHLKPLMT 490 ELLKRILDGN 500 KRVQEAACSA 510 FATLEEEACT 520 ELVPYLSYIL 530 DTLVFAFGKY 540 QHKNLLILYD 550 AIGTLADSVG 560 HHLNQPEYIQ 570 KLMPPLIQKW 580 NELKDEDKDL 590 FPLLECLSSV 600 ATALQSGFLP 610 YCEPVYQRCV 620 TLVQKTLAQA 630 MMYTQHPEQY 640 EAPDKDFMIV 650 ALDLLSGLAE 660 GLGGHVEQLV 670 ARSNIMTLLF 680 QCMQDSMPEV 690 RQSSFALLGD 700 LTKACFIHVK 710 PCIAEFMPIL 720 GTNLNPEFIS 730 VCNNATWAIG 740 EICMQMGAEM 750 QPYVQMVLNN 760 LVEIINRPNT 770 PKTLLENTGR 780 LTSPSAIPAI 790 TIGRLGYVCP 800 QEVAPMLQQF 810 IRPWCTSLRN 820 IRDNEEKDSA 830 FRGICMMIGV 840 NPGGVVQDFI 850 FFCDAVASWV 860 SPKDDLRDMF 870 YKILHGFKDQ 880 VGEDNWQQFS 890 EQFPPLLKER LAAFYGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006606 protein import into nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.