Search Results
Overview
| Uniprot ID | O14810 |
|---|---|
| Protein Name | Complexin-1 |
| Gene Name | CPLX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 99 | GSLTRPKKAIPPGCG |
Function
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior
Protein Sequence
10
MEFVMKQALG
20
GATKDMGKML
30
GGDEEKDPDA
40
AKKEEERQEA
50
LRQAEEERKA
60
KYAKMEAERE
70
AVRQGIRDKY
80
GIKKKEEREA
90
EAQAAMEANS
100
EGSLTRPKKA
110
IPPGCGDEVE
120
EEDESILDTV
130
IKYLPGPLQD
MLKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| Cellular Component | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0099145 | regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane |
| Biological Process | GO:0017157 | regulation of exocytosis |
| Biological Process | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.