Overview
| Uniprot ID | O14817 |
|---|
| Protein Name | Tetraspanin-4 |
|---|
| Gene Name | TSPAN4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 120 |
RYAQQDLKKGLHLYG |
Function
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed:31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed:31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed:36252000, PubMed:36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed:34439793)
Protein Sequence
10
MARACLQAVK
20
YLMFAFNLLF
30
WLGGCGVLGV
40
GIWLAATQGS
50
FATLSSSFPS
60
LSAANLLIIT
70
GAFVMAIGFV
80
GCLGAIKENK
90
CLLLTFFLLL
100
LLVFLLEATI
110
AILFFAYTDK
120
IDRYAQQDLK
130
KGLHLYGTQG
140
NVGLTNAWSI
150
IQTDFRCCGV
160
SNYTDWFEVY
170
NATRVPDSCC
180
LEFSESCGLH
190
APGTWWKAPC
200
YETVKVWLQE
210
NLLAVGIFGL
220
CTALVQILGL
230
TFAMTMYCQV
VKADTYCA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0031982 |
vesicle |
| Molecular Function |
GO:0003823 |
antigen binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.