Search Results
Overview
| Uniprot ID | O14832 |
|---|---|
| Protein Name | Phytanoyl-CoA dioxygenase, peroxisomal |
| Gene Name | PHYH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | MRDVTISKSEYAPSE |
| 116 | SEYAPSEKMITKVQD |
| 120 | PSEKMITKVQDFQED |
| 128 | VQDFQEDKELFRYCT |
| 218 | GTHKGSLKPHDYPKW |
| 276 | NKTQGFRKAISCHFA |
| 302 | TSQENIEKEVVGIAH |
Function
Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (PubMed:10744784, PubMed:12031666, PubMed:12923223, PubMed:9326939). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs (PubMed:10744784, PubMed:12923223)
Protein Sequence
10
MEQLRAAARL
20
QIVLGHLGRP
30
SAGAVVAHPT
40
SGTISSASFH
50
PQQFQYTLDN
60
NVLTLEQRKF
70
YEENGFLVIK
80
NLVPDADIQR
90
FRNEFEKICR
100
KEVKPLGLTV
110
MRDVTISKSE
120
YAPSEKMITK
130
VQDFQEDKEL
140
FRYCTLPEIL
150
KYVECFTGPN
160
IMAMHTMLIN
170
KPPDSGKKTS
180
RHPLHQDLHY
190
FPFRPSDLIV
200
CAWTAMEHIS
210
RNNGCLVVLP
220
GTHKGSLKPH
230
DYPKWEGGVN
240
KMFHGIQDYE
250
ENKARVHLVM
260
EKGDTVFFHP
270
LLIHGSGQNK
280
TQGFRKAISC
290
HFASADCHYI
300
DVKGTSQENI
310
EKEVVGIAHK
320
FFGAENSVNL
330
KDIWMFRARL
VKGERTNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097731 | 9+0 non-motile cilium |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0031418 | L-ascorbic acid binding |
| Molecular Function | GO:0048244 | phytanoyl-CoA dioxygenase activity |
| Biological Process | GO:0019606 | 2-oxobutyrate catabolic process |
| Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
| Biological Process | GO:0001561 | fatty acid alpha-oxidation |
| Biological Process | GO:0006720 | isoprenoid metabolic process |
| Biological Process | GO:0097089 | methyl-branched fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.