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Overview

Uniprot IDO14867
Protein NameTranscription regulator protein BACH1
Gene NameBACH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
156 HCQKTDLKLSLLDQR
185 NVQTPQCKLRRYQGN
232 PKYRKFQKAFGTDRV
578 AQRCRKRKLDCIQNL

Function

Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498)

Protein Sequence

10 MSLSENSVFA 20 YESSVHSTNV 30 LLSLNDQRKK 40 DVLCDVTIFV 50 EGQRFRAHRS 60 VLAACSSYFH 70 SRIVGQADGE 80 LNITLPEEVT 90 VKGFEPLIQF 100 AYTAKLILSK 110 ENVDEVCKCV 120 EFLSVHNIEE 130 SCFQFLKFKF 140 LDSTADQQEC 150 PRKKCFSSHC 160 QKTDLKLSLL 170 DQRDLETDEV 180 EEFLENKNVQ 190 TPQCKLRRYQ 200 GNAKASPPLQ 210 DSASQTYESM 220 CLEKDAALAL 230 PSLCPKYRKF 240 QKAFGTDRVR 250 TGESSVKDIH 260 ASVQPNERSE 270 NECLGGVPEC 280 RDLQVMLKCD 290 ESKLAMEPEE 300 TKKDPASQCP 310 TEKSEVTPFP 320 HNSSIDPHGL 330 YSLSLLHTYD 340 QYGDLNFAGM 350 QNTTVLTEKP 360 LSGTDVQEKT 370 FGESQDLPLK 380 SDLGTREDSS 390 VASSDRSSVE 400 REVAEHLAKG 410 FWSDICSTDT 420 PCQMQLSPAV 430 AKDGSEQISQ 440 KRSECPWLGI 450 RISESPEPGQ 460 RTFTTLSSVN 470 CPFISTLSTE 480 GCSSNLEIGN 490 DDYVSEPQQE 500 PCPYACVISL 510 GDDSETDTEG 520 DSESCSAREQ 530 ECEVKLPFNA 540 QRIISLSRND 550 FQSLLKMHKL 560 TPEQLDCIHD 570 IRRRSKNRIA 580 AQRCRKRKLD 590 CIQNLESEIE 600 KLQSEKESLL 610 KERDHILSTL 620 GETKQNLTGL 630 CQKVCKEAAL 640 SQEQIQILAK 650 YSAADCPLSF 660 LISEKDKSTP 670 DGELALPSIF 680 SLSDRPPAVL 690 PPCARGNSEP 700 GYARGQESQQ 710 MSTATSEQAG 720 PAEQCRQSGG 730 ISDFCQQMTD KCTTDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0020037 heme binding
Molecular Function GO:0098531 ligand-modulated transcription factor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.