Search Results
Overview
| Uniprot ID | O14907 |
|---|---|
| Protein Name | Tax1-binding protein 3 |
| Gene Name | TAX1BP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | FSEDKTDKGIYVTRV |
Function
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6
Protein Sequence
10
MSYIPGQPVT
20
AVVQRVEIHK
30
LRQGENLILG
40
FSIGGGIDQD
50
PSQNPFSEDK
60
TDKGIYVTRV
70
SEGGPAEIAG
80
LQIGDKIMQV
90
NGWDMTMVTH
100
DQARKRLTKR
110
SEEVVRLLVT
120
RQSLQKAVQQ
SMLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Biological Process | GO:2000009 | negative regulation of protein localization to cell surface |
| Biological Process | GO:0030178 | negative regulation of Wnt signaling pathway |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:0007266 | Rho protein signal transduction |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.