Search Results
Overview
| Uniprot ID | O14908 |
|---|---|
| Protein Name | PDZ domain-containing protein GIPC1 |
| Gene Name | GIPC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | LGLGRRKKAPPLVEN |
| 9 | PLGLGRRKKAPPLVE |
Function
May be involved in G protein-linked signaling
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0017022 | myosin binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0014047 | glutamate secretion |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0032467 | positive regulation of cytokinesis |
| Biological Process | GO:0048023 | positive regulation of melanin biosynthetic process |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0099171 | presynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0007266 | Rho protein signal transduction |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.