Search Results
Overview
| Uniprot ID | O14933 |
|---|---|
| Protein Name | Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| Gene Name | UBE2L6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | ENWKPCTKTCQVLEA |
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3
Protein Sequence
10
MMASMRVVKE
20
LEDLQKKPPP
30
YLRNLSSDDA
40
NVLVWHALLL
50
PDQPPYHLKA
60
FNLRISFPPE
70
YPFKPPMIKF
80
TTKIYHPNVD
90
ENGQICLPII
100
SSENWKPCTK
110
TCQVLEALNV
120
LVNRPNIREP
130
LRMDLADLLT
140
QNPELFRKNA
150
EEFTLRFGVD
RPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042296 | ISG15 transferase activity |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0032020 | ISG15-protein conjugation |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
PMID: N/A