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Overview

Uniprot IDO14936
Protein NamePeripheral plasma membrane protein CASK
Gene NameCASK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
20 ELCEVIGKGPFSVVR
305 FNARRKLKGAVLAAV
366 ALTDCSEKDLDFLHS
41 TGQQFAVKIVDVAKF

Function

Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity)

Protein Sequence

10 MADDDVLFED 20 VYELCEVIGK 30 GPFSVVRRCI 40 NRETGQQFAV 50 KIVDVAKFTS 60 SPGLSTEDLK 70 REASICHMLK 80 HPHIVELLET 90 YSSDGMLYMV 100 FEFMDGADLC 110 FEIVKRADAG 120 FVYSEAVASH 130 YMRQILEALR 140 YCHDNNIIHR 150 DVKPHCVLLA 160 SKENSAPVKL 170 GGFGVAIQLG 180 ESGLVAGGRV 190 GTPHFMAPEV 200 VKREPYGKPV 210 DVWGCGVILF 220 ILLSGCLPFY 230 GTKERLFEGI 240 IKGKYKMNPR 250 QWSHISESAK 260 DLVRRMLMLD 270 PAERITVYEA 280 LNHPWLKERD 290 RYAYKIHLPE 300 TVEQLRKFNA 310 RRKLKGAVLA 320 AVSSHKFNSF 330 YGDPPEELPD 340 FSEDPTSSGL 350 LAAERAVSQV 360 LDSLEEIHAL 370 TDCSEKDLDF 380 LHSVFQDQHL 390 HTLLDLYDKI 400 NTKSSPQIRN 410 PPSDAVQRAK 420 EVLEEISCYP 430 ENNDAKELKR 440 ILTQPHFMAL 450 LQTHDVVAHE 460 VYSDEALRVT 470 PPPTSPYLNG 480 DSPESANGDM 490 DMENVTRVRL 500 VQFQKNTDEP 510 MGITLKMNEL 520 NHCIVARIMH 530 GGMIHRQGTL 540 HVGDEIREIN 550 GISVANQTVE 560 QLQKMLREMR 570 GSITFKIVPS 580 YRTQSSSCER 590 DSPSTSRQSP 600 ANGHSSTNNS 610 VSDLPSTTQP 620 KGRQIYVRAQ 630 FEYDPAKDDL 640 IPCKEAGIRF 650 RVGDIIQIIS 660 KDDHNWWQGK 670 LENSKNGTAG 680 LIPSPELQEW 690 RVACIAMEKT 700 KQEQQASCTW 710 FGKKKKQYKD 720 KYLAKHNAVF 730 DQLDLVTYEE 740 VVKLPAFKRK 750 TLVLLGAHGV 760 GRRHIKNTLI 770 TKHPDRFAYP 780 IPHTTRPPKK 790 DEENGKNYYF 800 VSHDQMMQDI 810 SNNEYLEYGS 820 HEDAMYGTKL 830 ETIRKIHEQG 840 LIAILDVEPQ 850 ALKVLRTAEF 860 APFVVFIAAP 870 TITPGLNEDE 880 SLQRLQKESD 890 ILQRTYAHYF 900 DLTIINNEID 910 ETIRHLEEAV 920 ELVCTAPQWV PVSWVY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0060170 ciliary membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005652 nuclear lamina
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0031982 vesicle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0004385 GMP kinase activity
Molecular Function GO:0042043 neurexin family protein binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0001953 negative regulation of cell-matrix adhesion
Biological Process GO:0090288 negative regulation of cellular response to growth factor stimulus
Biological Process GO:0010839 negative regulation of keratinocyte proliferation
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0015031 protein transport
Biological Process GO:0046928 regulation of neurotransmitter secretion
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.