Search Results
Overview
| Uniprot ID | O14950 |
|---|---|
| Protein Name | Myosin regulatory light chain 12B |
| Gene Name | MYL12B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | REAPIDKKGNFNYIE |
Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion
Protein Sequence
10
MSSKKAKTKT
20
TKKRPQRATS
30
NVFAMFDQSQ
40
IQEFKEAFNM
50
IDQNRDGFID
60
KEDLHDMLAS
70
LGKNPTDAYL
80
DAMMNEAPGP
90
INFTMFLTMF
100
GEKLNGTDPE
110
DVIRNAFACF
120
DEEATGTIQE
130
DYLRELLTTM
140
GDRFTDEEVD
150
ELYREAPIDK
160
KGNFNYIEFT
170
RILKHGAKDK
DD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0016460 | myosin II complex |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0032036 | myosin heavy chain binding |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.