Search Results

Overview

Uniprot ID	O14964
Protein Name	Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene Name	HGS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
283	EKERLRQKSTYTSYP
521	LEIMRQKKQEYLEVQ

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Protein Sequence

10 MGRGSGTFER 20 LLDKATSQLL 30 LETDWESILQ 40 ICDLIRQGDT 50 QAKYAVNSIK 60 KKVNDKNPHV 70 ALYALEVMES 80 VVKNCGQTVH 90 DEVANKQTME 100 ELKDLLKRQV 110 EVNVRNKILY 120 LIQAWAHAFR 130 NEPKYKVVQD 140 TYQIMKVEGH 150 VFPEFKESDA 160 MFAAERAPDW 170 VDAEECHRCR 180 VQFGVMTRKH 190 HCRACGQIFC 200 GKCSSKYSTI 210 PKFGIEKEVR 220 VCEPCYEQLN 230 RKAEGKATST 240 TELPPEYLTS 250 PLSQQSQLPP 260 KRDETALQEE 270 EELQLALALS 280 QSEAEEKERL 290 RQKSTYTSYP 300 KAEPMPSASS 310 APPASSLYSS 320 PVNSSAPLAE 330 DIDPELARYL 340 NRNYWEKKQE 350 EARKSPTPSA 360 PVPLTEPAAQ 370 PGEGHAAPTN 380 VVENPLPETD 390 SQPIPPSGGP 400 FSEPQFHNGE 410 SEESHEQFLK 420 ALQNAVTTFV 430 NRMKSNHMRG 440 RSITNDSAVL 450 SLFQSINGMH 460 PQLLELLNQL 470 DERRLYYEGL 480 QDKLAQIRDA 490 RGALSALREE 500 HREKLRRAAE 510 EAERQRQIQL 520 AQKLEIMRQK 530 KQEYLEVQRQ 540 LAIQRLQEQE 550 KERQMRLEQQ 560 KQTVQMRAQM 570 PAFPLPYAQL 580 QAMPAAGGVL 590 YQPSGPASFP 600 STFSPAGSVE 610 GSPMHGVYMS 620 QPAPAAGPYP 630 SMPSTAADPS 640 MVSAYMYPAG 650 ATGAQAAPQA 660 QAGPTASPAY 670 SSYQPTPTAG 680 YQNVASQAPQ 690 SLPAISQPPQ 700 SSTMGYMGSQ 710 SVSMGYQPYN 720 MQNLMTTLPS 730 QDASLPPQQP 740 YIAGQQPMYQ 750 QMAPSGGPPQ 760 QQPPVAQQPQ 770 AQGPPAQGSE AQLISFD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0072657	protein localization to membrane
Biological Process	GO:0006622	protein targeting to lysosome
Biological Process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process	GO:0031623	receptor internalization
Biological Process	GO:0043405	regulation of MAP kinase activity
Biological Process	GO:0042176	regulation of protein catabolic process
Biological Process	GO:0007165	signal transduction
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0033565	ESCRT-0 complex
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0032585	multivesicular body membrane
Cellular Component	GO:0097013	phagocytic vesicle lumen
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0043130	ubiquitin binding
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0032456	endocytic recycling
Biological Process	GO:0016197	endosomal transport
Biological Process	GO:0016236	macroautophagy
Biological Process	GO:0090148	membrane fission
Biological Process	GO:0010324	membrane invagination
Biological Process	GO:0036258	multivesicular body assembly
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process	GO:1903543	positive regulation of exosomal secretion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.