Overview
| Uniprot ID | O14965 |
|---|
| Protein Name | Aurora kinase A |
|---|
| Gene Name | AURKA |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 143 |
GRPLGKGKFGNVYLA |
| 63 |
RIPLQAQKLVSSHKP |
| 99 |
LNNTQKSKQPLPSAP |
Function
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735)
Protein Sequence
10
MDRSKENCIS
20
GPVKATAPVG
30
GPKRVLVTQQ
40
FPCQNPLPVN
50
SGQAQRVLCP
60
SNSSQRIPLQ
70
AQKLVSSHKP
80
VQNQKQKQLQ
90
ATSVPHPVSR
100
PLNNTQKSKQ
110
PLPSAPENNP
120
EEELASKQKN
130
EESKKRQWAL
140
EDFEIGRPLG
150
KGKFGNVYLA
160
REKQSKFILA
170
LKVLFKAQLE
180
KAGVEHQLRR
190
EVEIQSHLRH
200
PNILRLYGYF
210
HDATRVYLIL
220
EYAPLGTVYR
230
ELQKLSKFDE
240
QRTATYITEL
250
ANALSYCHSK
260
RVIHRDIKPE
270
NLLLGSAGEL
280
KIADFGWSVH
290
APSSRRTTLC
300
GTLDYLPPEM
310
IEGRMHDEKV
320
DLWSLGVLCY
330
EFLVGKPPFE
340
ANTYQETYKR
350
ISRVEFTFPD
360
FVTEGARDLI
370
SRLLKHNPSQ
380
RPMLREVLEH
390
PWITANSSKP
400
SNCQNKESAS
KQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043203 |
axon hillock |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0097431 |
mitotic spindle pole |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:0005819 |
spindle |
| Cellular Component |
GO:0051233 |
spindle midzone |
| Cellular Component |
GO:0000922 |
spindle pole |
| Cellular Component |
GO:0031616 |
spindle pole centrosome |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0035175 |
histone H3S10 kinase activity |
| Molecular Function |
GO:0140677 |
molecular function activator activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0004672 |
protein kinase activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Molecular Function |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0061523 |
cilium disassembly |
| Biological Process |
GO:0000086 |
G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0097421 |
liver regeneration |
| Biological Process |
GO:0000212 |
meiotic spindle organization |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0007100 |
mitotic centrosome separation |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0032091 |
negative regulation of protein binding |
| Biological Process |
GO:0018105 |
peptidyl-serine phosphorylation |
| Biological Process |
GO:0090141 |
positive regulation of mitochondrial fission |
| Biological Process |
GO:0045931 |
positive regulation of mitotic cell cycle |
| Biological Process |
GO:0045840 |
positive regulation of mitotic nuclear division |
| Biological Process |
GO:0046777 |
protein autophosphorylation |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0046605 |
regulation of centrosome cycle |
| Biological Process |
GO:0032465 |
regulation of cytokinesis |
| Biological Process |
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0031647 |
regulation of protein stability |
| Biological Process |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
| Biological Process |
GO:0009611 |
response to wounding |
| Biological Process |
GO:0007051 |
spindle organization |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0032133 |
chromosome passenger complex |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0042585 |
germinal vesicle |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0072687 |
meiotic spindle |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.