Search Results
Overview
| Uniprot ID | O14967 |
|---|---|
| Protein Name | Calmegin |
| Gene Name | CLGN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 460 | ANKPGVLKQLMAAAE |
Function
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity)
Protein Sequence
10
MHFQAFWLCL
20
GLLFISINAE
30
FMDDDVETED
40
FEENSEEIDV
50
NESELSSEIK
60
YKTPQPIGEV
70
YFAETFDSGR
80
LAGWVLSKAK
90
KDDMDEEISI
100
YDGRWEIEEL
110
KENQVPGDRG
120
LVLKSRAKHH
130
AISAVLAKPF
140
IFADKPLIVQ
150
YEVNFQDGID
160
CGGAYIKLLA
170
DTDDLILENF
180
YDKTSYIIMF
190
GPDKCGEDYK
200
LHFIFRHKHP
210
KTGVFEEKHA
220
KPPDVDLKKF
230
FTDRKTHLYT
240
LVMNPDDTFE
250
VLVDQTVVNK
260
GSLLEDVVPP
270
IKPPKEIEDP
280
NDKKPEEWDE
290
RAKIPDPSAV
300
KPEDWDESEP
310
AQIEDSSVVK
320
PAGWLDDEPK
330
FIPDPNAEKP
340
DDWNEDTDGE
350
WEAPQILNPA
360
CRIGCGEWKP
370
PMIDNPKYKG
380
VWRPPLVDNP
390
NYQGIWSPRK
400
IPNPDYFEDD
410
HPFLLTSFSA
420
LGLELWSMTS
430
DIYFDNFIIC
440
SEKEVADHWA
450
ADGWRWKIMI
460
ANANKPGVLK
470
QLMAAAEGHP
480
WLWLIYLVTA
490
GVPIALITSF
500
CWPRKVKKKH
510
KDTEYKKTDI
520
CIPQTKGVLE
530
QEEKEEKAAL
540
EKPMDLEEEK
550
KQNDGEMLEK
560
EEESEPEEKS
570
EEEIEIIEGQ
580
EESNQSNKSG
590
SEDEMKEADE
600
STGSGDGPIK
610
SVRKRRVRKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0007338 | single fertilization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.