Search Results

Overview

Uniprot IDO14975
Protein NameLong-chain fatty acid transport protein 2
Gene NameSLC27A2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
141 LNYNIRAKSLLHCFQ
174 EILPSLKKDDVSIYY
291 ATLALRTKFSASQFW
325 YLCNSPQKPNDRDHK
419 GYCVRVPKGEVGLLV
572 IEITGTFKHRKMTLV
575 TGTFKHRKMTLVEEG

Function

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735)

Protein Sequence

10 MLSAIYTVLA 20 GLLFLPLLVN 30 LCCPYFFQDI 40 GYFLKVAAVG 50 RRVRSYGKRR 60 PARTILRAFL 70 EKARQTPHKP 80 FLLFRDETLT 90 YAQVDRRSNQ 100 VARALHDHLG 110 LRQGDCVALL 120 MGNEPAYVWL 130 WLGLVKLGCA 140 MACLNYNIRA 150 KSLLHCFQCC 160 GAKVLLVSPE 170 LQAAVEEILP 180 SLKKDDVSIY 190 YVSRTSNTDG 200 IDSFLDKVDE 210 VSTEPIPESW 220 RSEVTFSTPA 230 LYIYTSGTTG 240 LPKAAMITHQ 250 RIWYGTGLTF 260 VSGLKADDVI 270 YITLPFYHSA 280 ALLIGIHGCI 290 VAGATLALRT 300 KFSASQFWDD 310 CRKYNVTVIQ 320 YIGELLRYLC 330 NSPQKPNDRD 340 HKVRLALGNG 350 LRGDVWRQFV 360 KRFGDICIYE 370 FYAATEGNIG 380 FMNYARKVGA 390 VGRVNYLQKK 400 IITYDLIKYD 410 VEKDEPVRDE 420 NGYCVRVPKG 430 EVGLLVCKIT 440 QLTPFNGYAG 450 AKAQTEKKKL 460 RDVFKKGDLY 470 FNSGDLLMVD 480 HENFIYFHDR 490 VGDTFRWKGE 500 NVATTEVADT 510 VGLVDFVQEV 520 NVYGVHVPDH 530 EGRIGMASIK 540 MKENHEFDGK 550 KLFQHIADYL 560 PSYARPRFLR 570 IQDTIEITGT 580 FKHRKMTLVE 590 EGFNPAVIKD 600 ALYFLDDTAK 610 MYVPMTEDIY 620 NAISAKTLKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0035579 specific granule membrane
Molecular Function GO:0047676 arachidonate-CoA ligase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0047747 cholate-CoA ligase activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0005324 long-chain fatty acid transmembrane transporter activity
Molecular Function GO:0004467 long-chain fatty acid-CoA ligase activity
Molecular Function GO:0050197 phytanate-CoA ligase activity
Molecular Function GO:0070251 pristanate-CoA ligase activity
Molecular Function GO:0031957 very long-chain fatty acid-CoA ligase activity
Biological Process GO:0006699 bile acid biosynthetic process
Biological Process GO:0008206 bile acid metabolic process
Biological Process GO:0001561 fatty acid alpha-oxidation
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0046949 fatty-acyl-CoA biosynthetic process
Biological Process GO:0044539 long-chain fatty acid import into cell
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0097089 methyl-branched fatty acid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.