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Overview

Uniprot IDO14980
Protein NameExportin-1
Gene NameXPO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
122 SDPTCVEKEKVYIGK
124 PTCVEKEKVYIGKLN
568 FLKTVVNKLFEFMHE
680 TKNVDILKDPETVKQ
693 KQLGSILKTNVRACK

Function

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap

Protein Sequence

10 MPAIMTMLAD 20 HAARQLLDFS 30 QKLDINLLDN 40 VVNCLYHGEG 50 AQQRMAQEVL 60 THLKEHPDAW 70 TRVDTILEFS 80 QNMNTKYYGL 90 QILENVIKTR 100 WKILPRNQCE 110 GIKKYVVGLI 120 IKTSSDPTCV 130 EKEKVYIGKL 140 NMILVQILKQ 150 EWPKHWPTFI 160 SDIVGASRTS 170 ESLCQNNMVI 180 LKLLSEEVFD 190 FSSGQITQVK 200 SKHLKDSMCN 210 EFSQIFQLCQ 220 FVMENSQNAP 230 LVHATLETLL 240 RFLNWIPLGY 250 IFETKLISTL 260 IYKFLNVPMF 270 RNVSLKCLTE 280 IAGVSVSQYE 290 EQFVTLFTLT 300 MMQLKQMLPL 310 NTNIRLAYSN 320 GKDDEQNFIQ 330 NLSLFLCTFL 340 KEHDQLIEKR 350 LNLRETLMEA 360 LHYMLLVSEV 370 EETEIFKICL 380 EYWNHLAAEL 390 YRESPFSTSA 400 SPLLSGSQHF 410 DVPPRRQLYL 420 PMLFKVRLLM 430 VSRMAKPEEV 440 LVVENDQGEV 450 VREFMKDTDS 460 INLYKNMRET 470 LVYLTHLDYV 480 DTERIMTEKL 490 HNQVNGTEWS 500 WKNLNTLCWA 510 IGSISGAMHE 520 EDEKRFLVTV 530 IKDLLGLCEQ 540 KRGKDNKAII 550 ASNIMYIVGQ 560 YPRFLRAHWK 570 FLKTVVNKLF 580 EFMHETHDGV 590 QDMACDTFIK 600 IAQKCRRHFV 610 QVQVGEVMPF 620 IDEILNNINT 630 IICDLQPQQV 640 HTFYEAVGYM 650 IGAQTDQTVQ 660 EHLIEKYMLL 670 PNQVWDSIIQ 680 QATKNVDILK 690 DPETVKQLGS 700 ILKTNVRACK 710 AVGHPFVIQL 720 GRIYLDMLNV 730 YKCLSENISA 740 AIQANGEMVT 750 KQPLIRSMRT 760 VKRETLKLIS 770 GWVSRSNDPQ 780 MVAENFVPPL 790 LDAVLIDYQR 800 NVPAAREPEV 810 LSTMAIIVNK 820 LGGHITAEIP 830 QIFDAVFECT 840 LNMINKDFEE 850 YPEHRTNFFL 860 LLQAVNSHCF 870 PAFLAIPPTQ 880 FKLVLDSIIW 890 AFKHTMRNVA 900 DTGLQILFTL 910 LQNVAQEEAA 920 AQSFYQTYFC 930 DILQHIFSVV 940 TDTSHTAGLT 950 MHASILAYMF 960 NLVEEGKIST 970 SLNPGNPVNN 980 QIFLQEYVAN 990 LLKSAFPHLQ 1000 DAQVKLFVTG 1010 LFSLNQDIPA 1020 FKEHLRDFLV 1030 QIKEFAGEDT 1040 SDLFLEEREI 1050 ALRQADEEKH 1060 KRQMSVPGIF 1070 NPHEIPEEMC D

Gene Ontology

Classification GO ID Description
Biological Process GO:0000054 ribosomal subunit export from nucleus
Biological Process GO:0042254 ribosome biogenesis
Cellular Component GO:0005642 annulate lamellae
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:1902075 cellular response to salt
Biological Process GO:0071401 cellular response to triglyceride
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0000055 ribosomal large subunit export from nucleus
Biological Process GO:0000056 ribosomal small subunit export from nucleus

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.