Search Results

Overview

Uniprot ID	O14981
Protein Name	TATA-binding protein-associated factor 172
Gene Name	BTAF1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
217	NKAKRMAKLFAKQRS
248	EPEEKRRKIANVVIN

Function

Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner

Protein Sequence

10 MAVSRLDRLF 20 ILLDTGTTPV 30 TRKAAAQQLG 40 EVVKLHPHEL 50 NNLLSKVLIY 60 LRSANWDTRI 70 AAGQAVEAIV 80 KNVPEWNPVP 90 RTRQEPTSES 100 SMEDSPTTER 110 LNFDRFDICR 120 LLQHGASLLG 130 SAGAEFEVQD 140 EKSGEVDPKE 150 RIARQRKLLQ 160 KKLGLNMGEA 170 IGMSTEELFN 180 DEDLDYTPTS 190 ASFVNKQPTL 200 QAAELIDSEF 210 RAGMSNRQKN 220 KAKRMAKLFA 230 KQRSRDAVET 240 NEKSNDSTDG 250 EPEEKRRKIA 260 NVVINQSAND 270 SKVLIDNIPD 280 SSSLIEETNE 290 WPLESFCEEL 300 CNDLFNPSWE 310 VRHGAGTGLR 320 EILKAHGKSG 330 GKMGDSTLEE 340 MIQQHQEWLE 350 DLVIRLLCVF 360 ALDRFGDFVS 370 DEVVAPVRET 380 CAQTLGVVLK 390 HMNETGVHKT 400 VDVLLKLLTQ 410 EQWEVRHGGL 420 LGIKYALAVR 430 QDVINTLLPK 440 VLTRIIEGLQ 450 DLDDDVRAVA 460 AASLVPVVES 470 LVYLQTQKVP 480 FIINTLWDAL 490 LELDDLTAST 500 NSIMTLLSSL 510 LTYPQVQQCS 520 IQQSLTVLVP 530 RVWPFLHHTI 540 SSVRRAALET 550 LFTLLSTQDQ 560 NSSSWLIPIL 570 PDMLRHIFQF 580 CVLESSQEIL 590 DLIHKVWMEL 600 LSKASVQYVV 610 AAACPWMGAW 620 LCLMMQPSHL 630 PIDLNMLLEV 640 KARAKEKTGG 650 KVRQGQSQNK 660 EVLQEYIAGA 670 DTIMEDPATR 680 DFVVMRARMM 690 AAKLLGALCC 700 CICDPGVNVV 710 TQEIKPAESL 720 GQLLLFHLNS 730 KSALQRISVA 740 LVICEWAALQ 750 KECKAVTLAV 760 QPRLLDILSE 770 HLYYDEIAVP 780 FTRMQNECKQ 790 LISSLADVHI 800 EVGNRVNNNV 810 LTIDQASDLV 820 TTVFNEATSS 830 FDLNPQVLQQ 840 LDSKRQQVQM 850 TVTETNQEWQ 860 VLQLRVHTFA 870 ACAVVSLQQL 880 PEKLNPIIKP 890 LMETIKKEEN 900 TLVQNYAAQC 910 IAKLLQQCTT 920 RTPCPNSKII 930 KNLCSSLCVD 940 PYLTPCVTCP 950 VPTQSGQENS 960 KGSTSEKDGM 970 HHTVTKHRGI 980 ITLYRHQKAA 990 FAITSRRGPT 1000 PKAVKAQIAD 1010 LPAGSSGNIL 1020 VELDEAQKPY 1030 LVQRRGAEFA 1040 LTTIVKHFGG 1050 EMAVKLPHLW 1060 DAMVGPLRNT 1070 IDINNFDGKS 1080 LLDKGDSPAQ 1090 ELVNSLQVFE 1100 TAAASMDSEL 1110 HPLLVQHLPH 1120 LYMCLQYPST 1130 AVRHMAARCV 1140 GVMSKIATME 1150 TMNIFLEKVL 1160 PWLGAIDDSV 1170 KQEGAIEALA 1180 CVMEQLDVGI 1190 VPYIVLLVVP 1200 VLGRMSDQTD 1210 SVRFMATQCF 1220 ATLIRLMPLE 1230 AGIPDPPNMS 1240 AELIQLKAKE 1250 RHFLEQLLDG 1260 KKLENYKIPV 1270 PINAELRKYQ 1280 QDGVNWLAFL 1290 NKYKLHGILC 1300 DDMGLGKTLQ 1310 SICILAGDHC 1320 HRAQEYARSK 1330 LAECMPLPSL 1340 VVCPPTLTGH 1350 WVDEVGKFCS 1360 REYLNPLHYT 1370 GPPTERIRLQ 1380 HQVKRHNLIV 1390 ASYDVVRNDI 1400 DFFRNIKFNY 1410 CILDEGHVIK 1420 NGKTKLSKAV 1430 KQLTANYRII 1440 LSGTPIQNNV 1450 LELWSLFDFL 1460 MPGFLGTERQ 1470 FAARYGKPIL 1480 ASRDARSSSR 1490 EQEAGVLAMD 1500 ALHRQVLPFL 1510 LRRMKEDVLQ 1520 DLPPKIIQDY 1530 YCTLSPLQVQ 1540 LYEDFAKSRA 1550 KCDVDETVSS 1560 ATLSEETEKP 1570 KLKATGHVFQ 1580 ALQYLRKLCN 1590 HPALVLTPQH 1600 PEFKTTAEKL 1610 AVQNSSLHDI 1620 QHAPKLSALK 1630 QLLLDCGLGN 1640 GSTSESGTES 1650 VVAQHRILIF 1660 CQLKSMLDIV 1670 EHDLLKPHLP 1680 SVTYLRLDGS 1690 IPPGQRHSIV 1700 SRFNNDPSID 1710 VLLLTTHVGG 1720 LGLNLTGADT 1730 VVFVEHDWNP 1740 MRDLQAMDRA 1750 HRIGQKRVVN 1760 VYRLITRGTL 1770 EEKIMGLQKF 1780 KMNIANTVIS 1790 QENSSLQSMG 1800 TDQLLDLFTL 1810 DKDGKAEKAD 1820 TSTSGKASMK 1830 SILENLSDLW 1840 DQEQYDSEYS LENFMHSLK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0004386	helicase activity
Molecular Function	GO:0017025	TBP-class protein binding
Molecular Function	GO:0003712	transcription coregulator activity
Biological Process	GO:0035562	negative regulation of chromatin binding
Biological Process	GO:0045892	negative regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.