Overview
| Uniprot ID | O14986 |
|---|
| Protein Name | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
|---|
| Gene Name | PIP5K1B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 250 |
ETYNALMKTLQRDCR |
Function
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)
Protein Sequence
10
MSSAAENGEA
20
APGKQNEEKT
30
YKKTASSAIK
40
GAIQLGIGYT
50
VGNLTSKPER
60
DVLMQDFYVV
70
ESVFLPSEGS
80
NLTPAHHYPD
90
FRFKTYAPLA
100
FRYFRELFGI
110
KPDDYLYSIC
120
SEPLIELSNP
130
GASGSLFFVT
140
SDDEFIIKTV
150
QHKEAEFLQK
160
LLPGYYMNLN
170
QNPRTLLPKF
180
YGLYCMQSGG
190
INIRIVVMNN
200
VLPRSMRMHF
210
TYDLKGSTYK
220
RRASRKEREK
230
SNPTFKDLDF
240
LQDMHEGLYF
250
DTETYNALMK
260
TLQRDCRVLE
270
SFKIMDYSLL
280
LGIHFLDHSL
290
KEKEEETPQN
300
VPDAKRTGMQ
310
KVLYSTAMES
320
IQGPGKSGDG
330
IITENPDTMG
340
GIPAKSHRGE
350
KLLLFMGIID
360
ILQSYRLMKK
370
LEHSWKALVY
380
DGDTVSVHRP
390
SFYADRFLKF
400
MNSRVFKKIQ
410
ALKASPSKKR
420
CNSIAALKAT
430
SQEIVSSISQ
440
EWKDEKRDLL
450
TEGQSFSSLD
460
EEALGSRHRP
470
DLVPSTPSLF
480
EAASLATTIS
490
SSSLYVNEHY
500
PHDRPTLYSN
510
SKGLPSSSTF
520
TLEEGTIYLT
530
AEPNTLEVQD
540
DNASVLDVYL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0001931 |
uropod |
| Molecular Function |
GO:0000285 |
1-phosphatidylinositol-3-phosphate 5-kinase activity |
| Molecular Function |
GO:0016308 |
1-phosphatidylinositol-4-phosphate 5-kinase activity |
| Molecular Function |
GO:0052810 |
1-phosphatidylinositol-5-kinase activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0052742 |
phosphatidylinositol kinase activity |
| Biological Process |
GO:0006661 |
phosphatidylinositol biosynthetic process |
| Biological Process |
GO:0046854 |
phosphatidylinositol phosphate biosynthetic process |
| Biological Process |
GO:0051896 |
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.