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Overview

Uniprot IDO15014
Protein NameZinc finger protein 609
Gene NameZNF609
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1082 AKSVIIPKLDDSSKL
1109 SDASHLSKEASEAKT
1291 ASPSVTCKSSSESKA
1297 CKSSSESKALDILQQ
1310 QQHASHYKSKSPTIS
1312 HASHYKSKSPTISDK
393 TATASDSKGTSNSSK
441 PSSANKRKNKPLSDM
479 TGPLPGTKVEPTVLD
507 PNCNKKYKHINGLKY
582 HSPSPSSKFSTKGLC
586 PSSKFSTKGLCKKKL
647 PSSLKPEKIPSKSLK
749 ESPLTPGKVCRAEEG
84 PVPGPQGKEGKSKSK
87 GPQGKEGKSKSKRSK
97 SKRSKSGKDTSKPTP

Function

Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others

Protein Sequence

10 MSLSSGASGG 20 KGVDANPVET 30 YDSGDEWDIG 40 VGNLIIDLDA 50 DLEKDQQKLE 60 MSGSKEVGIP 70 APNAVATLPD 80 NIKFVTPVPG 90 PQGKEGKSKS 100 KRSKSGKDTS 110 KPTPGTSLFT 120 PSEGAASKKE 130 VQGRSGDGAN 140 AGGLVAAIAP 150 KGSEKAAKAS 160 RSVAGSKKEK 170 ENSSSKSKKE 180 RSEGVGTCSE 190 KDPGVLQPVP 200 LGGRGGQYDG 210 SAGVDTGAVE 220 PLGSIAIEPG 230 AALNPLGTKP 240 EPEEGENECR 250 LLKKVKSEKM 260 ESPVSTPAVL 270 PIHLLVPVVN 280 NDISSPCEQI 290 MVRTRSVGVN 300 TCDVALATEP 310 ECLGPCEPGT 320 SVNLEGIVWQ 330 ETEDGMLVVN 340 VTWRNKTYVG 350 TLLDCTRHDW 360 APPRFCDSPT 370 SDLEMRNGRG 380 RGKRMRPNSN 390 TPVNETATAS 400 DSKGTSNSSK 410 TRAGANSKGR 420 RGSQNSSEHR 430 PPASSTSEDV 440 KASPSSANKR 450 KNKPLSDMEL 460 NSSSEDSKGS 470 KRVRTNSMGS 480 ATGPLPGTKV 490 EPTVLDRNCP 500 SPVLIDCPHP 510 NCNKKYKHIN 520 GLKYHQAHAH 530 TDDDSKPEAD 540 GDSEYGEEPI 550 LHADLGSCNG 560 ASVSQKGSLS 570 PARSATPKVR 580 LVEPHSPSPS 590 SKFSTKGLCK 600 KKLSGEGDTD 610 LGALSNDGSD 620 DGPSVMDETS 630 NDAFDSLERK 640 CMEKEKCKKP 650 SSLKPEKIPS 660 KSLKSARPIA 670 PAIPPQQIYT 680 FQTATFTAAS 690 PGSSSGLTAT 700 VAQAMPNSPQ 710 LKPIQPKPTV 720 MGEPFTVNPA 730 LTPAKDKKKK 740 DKKKKESSKE 750 LESPLTPGKV 760 CRAEEGKSPF 770 RESSGDGMKM 780 EGLLNGSSDP 790 HQSRLASIKA 800 EADKIYSFTD 810 NAPSPSIGGS 820 SRLENTTPTQ 830 PLTPLHVVTQ 840 NGAEASSVKT 850 NSPAYSDISD 860 AGEDGEGKVD 870 SVKSKDAEQL 880 VKEGAKKTLF 890 PPQPQSKDSP 900 YYQGFESYYS 910 PSYAQSSPGA 920 LNPSSQAGVE 930 SQALKTKRDE 940 EPESIEGKVK 950 NDICEEKKPE 960 LSSSSQQPSV 970 IQQRPNMYMQ 980 SLYYNQYAYV 990 PPYGYSDQSY 1000 HTHLLSTNTA 1010 YRQQYEEQQK 1020 RQSLEQQQRG 1030 VDKKAEMGLK 1040 EREAALKEEW 1050 KQKPSIPPTL 1060 TKAPSLTDLV 1070 KSGPGKAKEP 1080 GADPAKSVII 1090 PKLDDSSKLP 1100 GQAPEGLKVK 1110 LSDASHLSKE 1120 ASEAKTGAEC 1130 GRQAEMDPIL 1140 WYRQEAEPRM 1150 WTYVYPAKYS 1160 DIKSEDERWK 1170 EERDRKLKEE 1180 RSRSKDSVPK 1190 EDGKESTSSD 1200 CKLPTSEESR 1210 LGSKEPRPSV 1220 HVPVSSPLTQ 1230 HQSYIPYMHG 1240 YSYSQSYDPN 1250 HPSYRSMPAV 1260 MMQNYPGSYL 1270 PSSYSFSPYG 1280 SKVSGGEDAD 1290 KARASPSVTC 1300 KSSSESKALD 1310 ILQQHASHYK 1320 SKSPTISDKT 1330 SQERDRGGCG 1340 VVGGGGSCSS 1350 VGGASGGERS 1360 VDRPRTSPSQ 1370 RLMSTHHHHH 1380 HLGYSLLPAQ 1390 YNLPYAAGLS 1400 STAIVASQQG 1410 STPSLYPPPR R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007517 muscle organ development
Biological Process GO:2001224 positive regulation of neuron migration
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:2000291 regulation of myoblast proliferation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.