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Overview

Uniprot IDO15031
Protein NamePlexin-B2
Gene NamePLXNB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1110 GVKKQVNKLIHARGT
77 GPALDNKKCTPPIEA

Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity)

Protein Sequence

10 MALQLWALTL 20 LGLLGAGASL 30 RPRKLDFFRS 40 EKELNHLAVD 50 EASGVVYLGA 60 VNALYQLDAK 70 LQLEQQVATG 80 PALDNKKCTP 90 PIEASQCHEA 100 EMTDNVNQLL 110 LLDPPRKRLV 120 ECGSLFKGIC 130 ALRALSNISL 140 RLFYEDGSGE 150 KSFVASNDEG 160 VATVGLVSST 170 GPGGDRVLFV 180 GKGNGPHDNG 190 IIVSTRLLDR 200 TDSREAFEAY 210 TDHATYKAGY 220 LSTNTQQFVA 230 AFEDGPYVFF 240 VFNQQDKHPA 250 RNRTLLARMC 260 REDPNYYSYL 270 EMDLQCRDPD 280 IHAAAFGTCL 290 AASVAAPGSG 300 RVLYAVFSRD 310 SRSSGGPGAG 320 LCLFPLDKVH 330 AKMEANRNAC 340 YTGTREARDI 350 FYKPFHGDIQ 360 CGGHAPGSSK 370 SFPCGSEHLP 380 YPLGSRDGLR 390 GTAVLQRGGL 400 NLTAVTVAAE 410 NNHTVAFLGT 420 SDGRILKVYL 430 TPDGTSSEYD 440 SILVEINKRV 450 KRDLVLSGDL 460 GSLYAMTQDK 470 VFRLPVQECL 480 SYPTCTQCRD 490 SQDPYCGWCV 500 VEGRCTRKAE 510 CPRAEEASHW 520 LWSRSKSCVA 530 VTSAQPQNMS 540 RRAQGEVQLT 550 VSPLPALSEE 560 DELLCLFGES 570 PPHPARVEGE 580 AVICNSPSSI 590 PVTPPGQDHV 600 AVTIQLLLRR 610 GNIFLTSYQY 620 PFYDCRQAMS 630 LEENLPCISC 640 VSNRWTCQWD 650 LRYHECREAS 660 PNPEDGIVRA 670 HMEDSCPQFL 680 GPSPLVIPMN 690 HETDVNFQGK 700 NLDTVKGSSL 710 HVGSDLLKFM 720 EPVTMQESGT 730 FAFRTPKLSH 740 DANETLPLHL 750 YVKSYGKNID 760 SKLHVTLYNC 770 SFGRSDCSLC 780 RAANPDYRCA 790 WCGGQSRCVY 800 EALCNTTSEC 810 PPPVITRIQP 820 ETGPLGGGIR 830 ITILGSNLGV 840 QAGDIQRISV 850 AGRNCSFQPE 860 RYSVSTRIVC 870 VIEAAETPFT 880 GGVEVDVFGK 890 LGRSPPNVQF 900 TFQQPKPLSV 910 EPQQGPQAGG 920 TTLTIHGTHL 930 DTGSQEDVRV 940 TLNGVPCKVT 950 KFGAQLQCVT 960 GPQATRGQML 970 LEVSYGGSPV 980 PNPGIFFTYR 990 ENPVLRAFEP 1000 LRSFASGGRS 1010 INVTGQGFSL 1020 IQRFAMVVIA 1030 EPLQSWQPPR 1040 EAESLQPMTV 1050 VGTDYVFHND 1060 TKVVFLSPAV 1070 PEEPEAYNLT 1080 VLIEMDGHRA 1090 LLRTEAGAFE 1100 YVPDPTFENF 1110 TGGVKKQVNK 1120 LIHARGTNLN 1130 KAMTLQEAEA 1140 FVGAERCTMK 1150 TLTETDLYCE 1160 PPEVQPPPKR 1170 RQKRDTTHNL 1180 PEFIVKFGSR 1190 EWVLGRVEYD 1200 TRVSDVPLSL 1210 ILPLVIVPMV 1220 VVIAVSVYCY 1230 WRKSQQAERE 1240 YEKIKSQLEG 1250 LEESVRDRCK 1260 KEFTDLMIEM 1270 EDQTNDVHEA 1280 GIPVLDYKTY 1290 TDRVFFLPSK 1300 DGDKDVMITG 1310 KLDIPEPRRP 1320 VVEQALYQFS 1330 NLLNSKSFLI 1340 NFIHTLENQR 1350 EFSARAKVYF 1360 ASLLTVALHG 1370 KLEYYTDIMH 1380 TLFLELLEQY 1390 VVAKNPKLML 1400 RRSETVVERM 1410 LSNWMSICLY 1420 QYLKDSAGEP 1430 LYKLFKAIKH 1440 QVEKGPVDAV 1450 QKKAKYTLND 1460 TGLLGDDVEY 1470 APLTVSVIVQ 1480 DEGVDAIPVK 1490 VLNCDTISQV 1500 KEKIIDQVYR 1510 GQPCSCWPRP 1520 DSVVLEWRPG 1530 STAQILSDLD 1540 LTSQREGRWK 1550 RVNTLMHYNV 1560 RDGATLILSK 1570 VGVSQQPEDS 1580 QQDLPGERHA 1590 LLEEENRVWH 1600 LVRPTDEVDE 1610 GKSKRGSVKE 1620 KERTKAITEI 1630 YLTRLLSVKG 1640 TLQQFVDNFF 1650 QSVLAPGHAV 1660 PPAVKYFFDF 1670 LDEQAEKHNI 1680 QDEDTIHIWK 1690 TNSLPLRFWV 1700 NILKNPHFIF 1710 DVHVHEVVDA 1720 SLSVIAQTFM 1730 DACTRTEHKL 1740 SRDSPSNKLL 1750 YAKEISTYKK 1760 MVEDYYKGIR 1770 QMVQVSDQDM 1780 NTHLAEISRA 1790 HTDSLNTLVA 1800 LHQLYQYTQK 1810 YYDEIINALE 1820 EDPAAQKMQL 1830 AFRLQQIAAA LENKVTDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:2001222 regulation of neuron migration
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:0007416 synapse assembly
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002116 semaphorin receptor complex
Molecular Function GO:0017154 semaphorin receptor activity
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0004888 transmembrane signaling receptor activity
Biological Process GO:0007420 brain development
Biological Process GO:1904861 excitatory synapse assembly
Biological Process GO:0007156 homophilic cell-cell adhesion
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0001843 neural tube closure
Biological Process GO:0007405 neuroblast proliferation
Biological Process GO:0050772 positive regulation of axonogenesis

Reference

PMID: N/A