Search Results
Overview
| Uniprot ID | O15041 |
|---|---|
| Protein Name | Semaphorin-3E |
| Gene Name | SEMA3E |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 91 | ERISDGYKEIHWPST |
Function
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)
Protein Sequence
10
MASAGHIITL
20
LLWGYLLELW
30
TGGHTADTTH
40
PRLRLSHKEL
50
LNLNRTSIFH
60
SPFGFLDLHT
70
MLLDEYQERL
80
FVGGRDLVYS
90
LSLERISDGY
100
KEIHWPSTAL
110
KMEECIMKGK
120
DAGECANYVR
130
VLHHYNRTHL
140
LTCGTGAFDP
150
VCAFIRVGYH
160
LEDPLFHLES
170
PRSERGRGRC
180
PFDPSSSFIS
190
TLIGSELFAG
200
LYSDYWSRDA
210
AIFRSMGRLA
220
HIRTEHDDER
230
LLKEPKFVGS
240
YMIPDNEDRD
250
DNKVYFFFTE
260
KALEAENNAH
270
AIYTRVGRLC
280
VNDVGGQRIL
290
VNKWSTFLKA
300
RLVCSVPGMN
310
GIDTYFDELE
320
DVFLLPTRDH
330
KNPVIFGLFN
340
TTSNIFRGHA
350
ICVYHMSSIR
360
AAFNGPYAHK
370
EGPEYHWSVY
380
EGKVPYPRPG
390
SCASKVNGGR
400
YGTTKDYPDD
410
AIRFARSHPL
420
MYQAIKPAHK
430
KPILVKTDGK
440
YNLKQIAVDR
450
VEAEDGQYDV
460
LFIGTDNGIV
470
LKVITIYNQE
480
MESMEEVILE
490
ELQIFKDPVP
500
IISMEISSKR
510
QQLYIGSASA
520
VAQVRFHHCD
530
MYGSACADCC
540
LARDPYCAWD
550
GISCSRYYPT
560
GTHAKRRFRR
570
QDVRHGNAAQ
580
QCFGQQFVGD
590
ALDKTEEHLA
600
YGIENNSTLL
610
ECTPRSLQAK
620
VIWFVQKGRE
630
TRKEEVKTDD
640
RVVKMDLGLL
650
FLRLHKSDAG
660
TYFCQTVEHS
670
FVHTVRKITL
680
EVVEEEKVED
690
MFNKDDEEDR
700
HHRMPCPAQS
710
SISQGAKPWY
720
KEFLQLIGYS
730
NFQRVEEYCE
740
KVWCTDRKRK
750
KLKMSPSKWK
760
YANPQEKKLR
770
SKPEHYRLPR
HTLDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0045499 | chemorepellent activity |
| Molecular Function | GO:0038191 | neuropilin binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0030215 | semaphorin receptor binding |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0001569 | branching involved in blood vessel morphogenesis |
| Biological Process | GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| Biological Process | GO:0050919 | negative chemotaxis |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0001953 | negative regulation of cell-matrix adhesion |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
| Biological Process | GO:0002040 | sprouting angiogenesis |
| Biological Process | GO:0050808 | synapse organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.