Search Results

Overview

Uniprot IDO15042
Protein NameU2 snRNP-associated SURP motif-containing protein
Gene NameU2SURP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 KTPGGSQKASSKTRS
153 EEHETDEKRGKIYKP
156 ETDEKRGKIYKPSSR
168 SSRFADQKNPPNQSS
188 SLLVIETKKPPLKKG
201 KGEKEKKKSNLELFK
392 AQPRERLKNPNAPML
4 ****MADKTPGGSQK
405 MLPPPKNKEDFEKTL
749 DATEDSKKNEPIFKV
755 KKNEPIFKVAPSKWE
760 IFKVAPSKWEAVDES
80 SRPLLENKLKAFSIG
82 PLLENKLKAFSIGKM
829 KEEMTESKFSKYSEM
832 MTESKFSKYSEMSEE
865 LESGKRPKKPGQSFQ
88 LKAFSIGKMSTAKRT
98 TAKRTLSKKEQEELK

Function

No function data available.

Protein Sequence

10 MADKTPGGSQ 20 KASSKTRSSD 30 VHSSGSSDAH 40 MDASGPSDSD 50 MPSRTRPKSP 60 RKHNYRNESA 70 RESLCDSPHQ 80 NLSRPLLENK 90 LKAFSIGKMS 100 TAKRTLSKKE 110 QEELKKKEDE 120 KAAAEIYEEF 130 LAAFEGSDGN 140 KVKTFVRGGV 150 VNAAKEEHET 160 DEKRGKIYKP 170 SSRFADQKNP 180 PNQSSNERPP 190 SLLVIETKKP 200 PLKKGEKEKK 210 KSNLELFKEE 220 LKQIQEERDE 230 RHKTKGRLSR 240 FEPPQSDSDG 250 QRRSMDAPSR 260 RNRSSGVLDD 270 YAPGSHDVGD 280 PSTTNLYLGN 290 INPQMNEEML 300 CQEFGRFGPL 310 ASVKIMWPRT 320 DEERARERNC 330 GFVAFMNRRD 340 AERALKNLNG 350 KMIMSFEMKL 360 GWGKAVPIPP 370 HPIYIPPSMM 380 EHTLPPPPSG 390 LPFNAQPRER 400 LKNPNAPMLP 410 PPKNKEDFEK 420 TLSQAIVKVV 430 IPTERNLLAL 440 IHRMIEFVVR 450 EGPMFEAMIM 460 NREINNPMFR 470 FLFENQTPAH 480 VYYRWKLYSI 490 LQGDSPTKWR 500 TEDFRMFKNG 510 SFWRPPPLNP 520 YLHGMSEEQE 530 TEAFVEEPSK 540 KGALKEEQRD 550 KLEEILRGLT 560 PRKNDIGDAM 570 VFCLNNAEAA 580 EEIVDCITES 590 LSILKTPLPK 600 KIARLYLVSD 610 VLYNSSAKVA 620 NASYYRKFFE 630 TKLCQIFSDL 640 NATYRTIQGH 650 LQSENFKQRV 660 MTCFRAWEDW 670 AIYPEPFLIK 680 LQNIFLGLVN 690 IIEEKETEDV 700 PDDLDGAPIE 710 EELDGAPLED 720 VDGIPIDATP 730 IDDLDGVPIK 740 SLDDDLDGVP 750 LDATEDSKKN 760 EPIFKVAPSK 770 WEAVDESELE 780 AQAVTTSKWE 790 LFDQHEESEE 800 EENQNQEEES 810 EDEEDTQSSK 820 SEEHHLYSNP 830 IKEEMTESKF 840 SKYSEMSEEK 850 RAKLREIELK 860 VMKFQDELES 870 GKRPKKPGQS 880 FQEQVEHYRD 890 KLLQREKEKE 900 LERERERDKK 910 DKEKLESRSK 920 DKKEKDECTP 930 TRKERKRRHS 940 TSPSPSRSSS 950 GRRVKSPSPK 960 SERSERSERS 970 HKESSRSRSS 980 HKDSPRDVSK 990 KAKRSPSGSR 1000 TPKRSRRSRS 1010 RSPKKSGKKS 1020 RSQSRSPHRS HKKSKKNKH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005686 U2 snRNP
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006396 RNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.