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Overview

Uniprot ID	O15047
Protein Name	Histone-lysine N-methyltransferase SETD1A
Gene Name	SETD1A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
203	GGKALSEKFQGSGAA

Function

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223)

Protein Sequence

10 MDQEGGGDGQ 20 KAPSFQWRNY 30 KLIVDPALDP 40 ALRRPSQKVY 50 RYDGVHFSVN 60 DSKYIPVEDL 70 QDPRCHVRSK 80 NRDFSLPVPK 90 FKLDEFYIGQ 100 IPLKEVTFAR 110 LNDNVRETFL 120 KDMCRKYGEV 130 EEVEILLHPR 140 TRKHLGLARV 150 LFTSTRGAKE 160 TVKNLHLTSV 170 MGNIIHAQLD 180 IKGQQRMKYY 190 ELIVNGSYTP 200 QTVPTGGKAL 210 SEKFQGSGAA 220 TETAESRRRS 230 SSDTAAYPAG 240 TTAVGTPGNG 250 TPCSQDTSFS 260 SSRQDTPSSF 270 GQFTPQSSQG 280 TPYTSRGSTP 290 YSQDSAYSSS 300 TTSTSFKPRR 310 SENSYQDAFS 320 RRHFSASSAS 330 TTASTAIAAT 340 TAATASSSAS 350 SSSLSSSSSS 360 SSSSSSSQFR 370 SSDANYPAYY 380 ESWNRYQRHT 390 SYPPRRATRE 400 EPPGAPFAEN 410 TAERFPPSYT 420 SYLPPEPSRP 430 TDQDYRPPAS 440 EAPPPEPPEP 450 GGGGGGGGPS 460 PEREEVRTSP 470 RPASPARSGS 480 PAPETTNESV 490 PFAQHSSLDS 500 RIEMLLKEQR 510 SKFSFLASDT 520 EEEEENSSMV 530 LGARDTGSEV 540 PSGSGHGPCT 550 PPPAPANFED 560 VAPTGSGEPG 570 ATRESPKANG 580 QNQASPCSSG 590 DDMEISDDDR 600 GGSPPPAPTP 610 PQQPPPPPPP 620 PPPPPPYLAS 630 LPLGYPPHQP 640 AYLLPPRPDG 650 PPPPEYPPPP 660 PPPPHIYDFV 670 NSLELMDRLG 680 AQWGGMPMSF 690 QMQTQMLTRL 700 HQLRQGKGLI 710 AASAGPPGGA 720 FGEAFLPFPP 730 PQEAAYGLPY 740 ALYAQGQEGR 750 GAYSREAYHL 760 PMPMAAEPLP 770 SSSVSGEEAR 780 LPPREEAELA 790 EGKTLPTAGT 800 VGRVLAMLVQ 810 EMKSIMQRDL 820 NRKMVENVAF 830 GAFDQWWESK 840 EEKAKPFQNA 850 AKQQAKEEDK 860 EKTKLKEPGL 870 LSLVDWAKSG 880 GTTGIEAFAF 890 GSGLRGALRL 900 PSFKVKRKEP 910 SEISEASEEK 920 RPRPSTPAEE 930 DEDDPEQEKE 940 AGEPGRPGTK 950 PPKRDEERGK 960 TQGKHRKSFA 970 LDSEGEEASQ 980 ESSSEKDEED 990 DEEDEEDEDR 1000 EEAVDTTKKE 1010 TEVSDGEDEE 1020 SDSSSKCSLY 1030 ADSDGENDST 1040 SDSESSSSSS 1050 SSSSSSSSSS 1060 SSSSSSSSES 1070 SSEDEEEEER 1080 PAALPSASPP 1090 PREVPVPTPA 1100 PVEVPVPERV 1110 AGSPVTPLPE 1120 QEASPARPAG 1130 PTEESPPSAP 1140 LRPPEPPAGP 1150 PAPAPRPDER 1160 PSSPIPLLPP 1170 PKKRRKTVSF 1180 SAIEVVPAPE 1190 PPPATPPQAK 1200 FPGPASRKAP 1210 RGVERTIRNL 1220 PLDHASLVKS 1230 WPEEVSRGGR 1240 SRAGGRGRLT 1250 EEEEAEPGTE 1260 VDLAVLADLA 1270 LTPARRGLPA 1280 LPAVEDSEAT 1290 ETSDEAERPR 1300 PLLSHILLEH 1310 NYALAVKPTP 1320 PAPALRPPEP 1330 VPAPAALFSS 1340 PADEVLEAPE 1350 VVVAEAEEPK 1360 PQQLQQQREE 1370 GEEEGEEEGE 1380 EEEEESSDSS 1390 SSSDGEGALR 1400 RRSLRSHARR 1410 RRPPPPPPPP 1420 PPRAYEPRSE 1430 FEQMTILYDI 1440 WNSGLDSEDM 1450 SYLRLTYERL 1460 LQQTSGADWL 1470 NDTHWVHHTI 1480 TNLTTPKRKR 1490 RPQDGPREHQ 1500 TGSARSEGYY 1510 PISKKEKDKY 1520 LDVCPVSARQ 1530 LEGVDTQGTN 1540 RVLSERRSEQ 1550 RRLLSAIGTS 1560 AIMDSDLLKL 1570 NQLKFRKKKL 1580 RFGRSRIHEW 1590 GLFAMEPIAA 1600 DEMVIEYVGQ 1610 NIRQMVADMR 1620 EKRYVQEGIG 1630 SSYLFRVDHD 1640 TIIDATKCGN 1650 LARFINHCCT 1660 PNCYAKVITI 1670 ESQKKIVIYS 1680 KQPIGVDEEI 1690 TYDYKFPLED 1700 NKIPCLCGTE SCRGSLN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0035097	histone methyltransferase complex
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048188	Set1C/COMPASS complex
Molecular Function	GO:0008013	beta-catenin binding
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity
Molecular Function	GO:0140945	histone H3K4 monomethyltransferase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process	GO:0007420	brain development
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0032259	methylation
Biological Process	GO:1902275	regulation of chromatin organization
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation

Reference

PMID: N/A