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Overview

Uniprot ID	O15075
Protein Name	Serine/threonine-protein kinase DCLK1
Gene Name	DCLK1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
170	VSSLATAKGSPSEVR
232	KLDSGVVKRLYTLDG
329	LSTPRSGKSPSPSPT
710	QDVRSRYKAQPAPPE

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system

Protein Sequence

10 MSFGRDMELE 20 HFDERDKAQR 30 YSRGSRVNGL 40 PSPTHSAHCS 50 FYRTRTLQTL 60 SSEKKAKKVR 70 FYRNGDRYFK 80 GIVYAISPDR 90 FRSFEALLAD 100 LTRTLSDNVN 110 LPQGVRTIYT 120 IDGLKKISSL 130 DQLVEGESYV 140 CGSIEPFKKL 150 EYTKNVNPNW 160 SVNVKTTSAS 170 RAVSSLATAK 180 GSPSEVRENK 190 DFIRPKLVTI 200 IRSGVKPRKA 210 VRILLNKKTA 220 HSFEQVLTDI 230 TDAIKLDSGV 240 VKRLYTLDGK 250 QVMCLQDFFG 260 DDDIFIACGP 270 EKFRYQDDFL 280 LDESECRVVK 290 STSYTKIASS 300 SRRSTTKSPG 310 PSRRSKSPAS 320 TSSVNGTPGS 330 QLSTPRSGKS 340 PSPSPTSPGS 350 LRKQRSSQHG 360 GSSTSLASTK 370 VCSSMDENDG 380 PGEEVSEEGF 390 QIPATITERY 400 KVGRTIGDGN 410 FAVVKECVER 420 STAREYALKI 430 IKKSKCRGKE 440 HMIQNEVSIL 450 RRVKHPNIVL 460 LIEEMDVPTE 470 LYLVMELVKG 480 GDLFDAITST 490 NKYTERDASG 500 MLYNLASAIK 510 YLHSLNIVHR 520 DIKPENLLVY 530 EHQDGSKSLK 540 LGDFGLATIV 550 DGPLYTVCGT 560 PTYVAPEIIA 570 ETGYGLKVDI 580 WAAGVITYIL 590 LCGFPPFRGS 600 GDDQEVLFDQ 610 ILMGQVDFPS 620 PYWDNVSDSA 630 KELITMMLLV 640 DVDQRFSAVQ 650 VLEHPWVNDD 660 GLPENEHQLS 670 VAGKIKKHFN 680 TGPKPNSTAA 690 GVSVIATTAL 700 DKERQVFRRR 710 RNQDVRSRYK 720 AQPAPPELNS 730 ESEDYSPSSS 740 ETVRSPNSPF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Biological Process	GO:0048675	axon extension
Biological Process	GO:0007417	central nervous system development
Biological Process	GO:0016197	endosomal transport
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0009615	response to virus

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.