Search Results

Overview

Uniprot ID	O15078
Protein Name	Centrosomal protein of 290 kDa
Gene Name	CEP290
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1829	LNNELQKKQKAYNKI
1831	NELQKKQKAYNKILR
975	QYNELTAKYRDILQK

Function

Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973)

Protein Sequence

10 MPPNINWKEI 20 MKVDPDDLPR 30 QEELADNLLI 40 SLSKVEVNEL 50 KSEKQENVIH 60 LFRITQSLMK 70 MKAQEVELAL 80 EEVEKAGEEQ 90 AKFENQLKTK 100 VMKLENELEM 110 AQQSAGGRDT 120 RFLRNEICQL 130 EKQLEQKDRE 140 LEDMEKELEK 150 EKKVNEQLAL 160 RNEEAENENS 170 KLRRENKRLK 180 KKNEQLCQDI 190 IDYQKQIDSQ 200 KETLLSRRGE 210 DSDYRSQLSK 220 KNYELIQYLD 230 EIQTLTEANE 240 KIEVQNQEMR 250 KNLEESVQEM 260 EKMTDEYNRM 270 KAIVHQTDNV 280 IDQLKKENDH 290 YQLQVQELTD 300 LLKSKNEEDD 310 PIMVAVNAKV 320 EEWKLILSSK 330 DDEIIEYQQM 340 LHNLREKLKN 350 AQLDADKSNV 360 MALQQGIQER 370 DSQIKMLTEQ 380 VEQYTKEMEK 390 NTCIIEDLKN 400 ELQRNKGAST 410 LSQQTHMKIQ 420 STLDILKEKT 430 KEAERTAELA 440 EADAREKDKE 450 LVEALKRLKD 460 YESGVYGLED 470 AVVEIKNCKN 480 QIKIRDREIE 490 ILTKEINKLE 500 LKISDFLDEN 510 EALRERVGLE 520 PKTMIDLTEF 530 RNSKHLKQQQ 540 YRAENQILLK 550 EIESLEEERL 560 DLKKKIRQMA 570 QERGKRSATS 580 GLTTEDLNLT 590 ENISQGDRIS 600 ERKLDLLSLK 610 NMSEAQSKNE 620 FLSRELIEKE 630 RDLERSRTVI 640 AKFQNKLKEL 650 VEENKQLEEG 660 MKEILQAIKE 670 MQKDPDVKGG 680 ETSLIIPSLE 690 RLVNAIESKN 700 AEGIFDASLH 710 LKAQVDQLTG 720 RNEELRQELR 730 ESRKEAINYS 740 QQLAKANLKI 750 DHLEKETSLL 760 RQSEGSNVVF 770 KGIDLPDGIA 780 PSSASIINSQ 790 NEYLIHLLQE 800 LENKEKKLKN 810 LEDSLEDYNR 820 KFAVIRHQQS 830 LLYKEYLSEK 840 ETWKTESKTI 850 KEEKRKLEDQ 860 VQQDAIKVKE 870 YNNLLNALQM 880 DSDEMKKILA 890 ENSRKITVLQ 900 VNEKSLIRQY 910 TTLVELERQL 920 RKENEKQKNE 930 LLSMEAEVCE 940 KIGCLQRFKE 950 MAIFKIAALQ 960 KVVDNSVSLS 970 ELELANKQYN 980 ELTAKYRDIL 990 QKDNMLVQRT 1000 SNLEHLECEN 1010 ISLKEQVESI 1020 NKELEITKEK 1030 LHTIEQAWEQ 1040 ETKLGNESSM 1050 DKAKKSITNS 1060 DIVSISKKIT 1070 MLEMKELNER 1080 QRAEHCQKMY 1090 EHLRTSLKQM 1100 EERNFELETK 1110 FAELTKINLD 1120 AQKVEQMLRD 1130 ELADSVSKAV 1140 SDADRQRILE 1150 LEKNEMELKV 1160 EVSKLREISD 1170 IARRQVEILN 1180 AQQQSRDKEV 1190 ESLRMQLLDY 1200 QAQSDEKSLI 1210 AKLHQHNVSL 1220 QLSEATALGK 1230 LESITSKLQK 1240 MEAYNLRLEQ 1250 KLDEKEQALY 1260 YARLEGRNRA 1270 KHLRQTIQSL 1280 RRQFSGALPL 1290 AQQEKFSKTM 1300 IQLQNDKLKI 1310 MQEMKNSQQE 1320 HRNMENKTLE 1330 MELKLKGLEE 1340 LISTLKDTKG 1350 AQKVINWHMK 1360 IEELRLQELK 1370 LNRELVKDKE 1380 EIKYLNNIIS 1390 EYERTISSLE 1400 EEIVQQNKFH 1410 EERQMAWDQR 1420 EVDLERQLDI 1430 FDRQQNEILN 1440 AAQKFEEATG 1450 SIPDPSLPLP 1460 NQLEIALRKI 1470 KENIRIILET 1480 RATCKSLEEK 1490 LKEKESALRL 1500 AEQNILSRDK 1510 VINELRLRLP 1520 ATAEREKLIA 1530 ELGRKEMEPK 1540 SHHTLKIAHQ 1550 TIANMQARLN 1560 QKEEVLKKYQ 1570 RLLEKAREEQ 1580 REIVKKHEED 1590 LHILHHRLEL 1600 QADSSLNKFK 1610 QTAWDLMKQS 1620 PTPVPTNKHF 1630 IRLAEMEQTV 1640 AEQDDSLSSL 1650 LVKLKKVSQD 1660 LERQREITEL 1670 KVKEFENIKL 1680 QLQENHEDEV 1690 KKVKAEVEDL 1700 KYLLDQSQKE 1710 SQCLKSELQA 1720 QKEANSRAPT 1730 TTMRNLVERL 1740 KSQLALKEKQ 1750 QKALSRALLE 1760 LRAEMTAAAE 1770 ERIISATSQK 1780 EAHLNVQQIV 1790 DRHTRELKTQ 1800 VEDLNENLLK 1810 LKEALKTSKN 1820 RENSLTDNLN 1830 DLNNELQKKQ 1840 KAYNKILREK 1850 EEIDQENDEL 1860 KRQIKRLTSG 1870 LQGKPLTDNK 1880 QSLIEELQRK 1890 VKKLENQLEG 1900 KVEEVDLKPM 1910 KEKNAKEELI 1920 RWEEGKKWQA 1930 KIEGIRNKLK 1940 EKEGEVFTLT 1950 KQLNTLKDLF 1960 AKADKEKLTL 1970 QRKLKTTGMT 1980 VDQVLGIRAL 1990 ESEKELEELK 2000 KRNLDLENDI 2010 LYMRAHQALP 2020 RDSVVEDLHL 2030 QNRYLQEKLH 2040 ALEKQFSKDT 2050 YSKPSISGIE 2060 SDDHCQREQE 2070 LQKENLKLSS 2080 ENIELKFQLE 2090 QANKDLPRLK 2100 NQVRDLKEMC 2110 EFLKKEKAEV 2120 QRKLGHVRGS 2130 GRSGKTIPEL 2140 EKTIGLMKKV 2150 VEKVQRENEQ 2160 LKKASGILTS 2170 EKMANIEQEN 2180 EKLKAELEKL 2190 KAHLGHQLSM 2200 HYESKTKGTE 2210 KIIAENERLR 2220 KELKKETDAA 2230 EKLRIAKNNL 2240 EILNEKMTVQ 2250 LEETGKRLQF 2260 AESRGPQLEG 2270 ADSKSWKSIV 2280 VTRMYETKLK 2290 ELETDIAKKN 2300 QSITDLKQLV 2310 KEATEREQKV 2320 NKYNEDLEQQ 2330 IKILKHVPEG 2340 AETEQGLKRE 2350 LQVLRLANHQ 2360 LDKEKAELIH 2370 QIEANKDQSG 2380 AESTIPDADQ 2390 LKEKIKDLET 2400 QLKMSDLEKQ 2410 HLKEEIKKLK 2420 KELENFDPSF 2430 FEEIEDLKYN 2440 YKEEVKKNIL 2450 LEEKVKKLSE 2460 QLGVELTSPV 2470 AASEEFEDEE ESPVNFPIY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0036038	MKS complex
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032391	photoreceptor connecting cilium
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0035580	specific granule lumen
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0043010	camera-type eye development
Biological Process	GO:0097711	ciliary basal body-plasma membrane docking
Biological Process	GO:1905349	ciliary transition zone assembly
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0042462	eye photoreceptor cell development
Biological Process	GO:0030902	hindbrain development
Biological Process	GO:0001822	kidney development
Biological Process	GO:1905515	non-motile cilium assembly
Biological Process	GO:0030916	otic vesicle formation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0090316	positive regulation of intracellular protein transport
Biological Process	GO:0048793	pronephros development
Biological Process	GO:1904491	protein localization to ciliary transition zone
Biological Process	GO:0015031	protein transport
Biological Process	GO:0070201	regulation of establishment of protein localization
Cellular Component	GO:0034451	centriolar satellite
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0035869	ciliary transition zone
Cellular Component	GO:0005737	cytoplasm

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.