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Overview

Uniprot IDO15085
Protein NameRho guanine nucleotide exchange factor 11
Gene NameARHGEF11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
538 KKRNPILKYIGKPKS

Function

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth

Protein Sequence

10 MSVRLPQSID 20 RLSSLSSLGD 30 SAPERKSPSH 40 HRQPSDASET 50 TGLVQRCVII 60 QKDQHGFGFT 70 VSGDRIVLVQ 80 SVRPGGAAMK 90 AGVKEGDRII 100 KVNGTMVTNS 110 SHLEVVKLIK 120 SGAYVALTLL 130 GSSPSSMGIS 140 GLQQDPSPAG 150 APRITSVIPS 160 PPPPPPLPPP 170 QRITGPKPLQ 180 DPEVQKHATQ 190 ILRNMLRQEE 200 KELQDILPLY 210 GDTSQRPSEG 220 RLSLDSQEGD 230 SGLDSGTERF 240 PSLSESLMNR 250 NSVLSDPGLD 260 SPRTSPVIMA 270 RVAQHHRRQG 280 SDAAVPSTGD 290 QGVDQSPKPL 300 IIGPEEDYDP 310 GYFNNESDII 320 FQDLEKLKSR 330 PAHLGVFLRY 340 IFSQADPSPL 350 LFYLCAEVYQ 360 QASPKDSRSL 370 GKDIWNIFLE 380 KNAPLRVKIP 390 EMLQAEIDSR 400 LRNSEDARGV 410 LCEAQEAAMP 420 EIQEQIHDYR 430 TKRTLGLGSL 440 YGENDLLDLD 450 GDPLRERQVA 460 EKQLAALGDI 470 LSKYEEDRSA 480 PMDFALNTYM 490 SHAGIRLREA 500 RPSNTAEKAQ 510 SAPDKDKWLP 520 FFPKTKKSSN 530 SKKEKDALED 540 KKRNPILKYI 550 GKPKSSSQST 560 FHIPLSPVEV 570 KPGNVRNIIQ 580 HFENNQQYDA 590 PEPGTQRLST 600 GSFPEDLLES 610 DSSRSEIRLG 620 RSESLKGREE 630 MKRSRKAENV 640 PRSRSDVDMD 650 AAAEATRLHQ 660 SASSSTSSLS 670 TRSLENPTPP 680 FTPKMGRRSI 690 ESPSLGFCTD 700 TLLPHLLEDD 710 LGQLSDLEPE 720 PDAQNWQHTV 730 GKDVVAGLTQ 740 REIDRQEVIN 750 ELFVTEASHL 760 RTLRVLDLIF 770 YQRMKKENLM 780 PREELARLFP 790 NLPELIEIHN 800 SWCEAMKKLR 810 EEGPIIKEIS 820 DLMLARFDGP 830 AREELQQVAA 840 QFCSYQSIAL 850 ELIKTKQRKE 860 SRFQLFMQEA 870 ESHPQCRRLQ 880 LRDLIISEMQ 890 RLTKYPLLLE 900 SIIKHTEGGT 910 SEHEKLCRAR 920 DQCREILKYV 930 NEAVKQTENR 940 HRLEGYQKRL 950 DATALERASN 960 PLAAEFKSLD 970 LTTRKMIHEG 980 PLTWRISKDK 990 TLDLHVLLLE 1000 DLLVLLQKQD 1010 EKLLLKCHSK 1020 TAVGSSDSKQ 1030 TFSPVLKLNA 1040 VLIRSVATDK 1050 RAFFIICTSK 1060 LGPPQIYELV 1070 ALTSSDKNTW 1080 MELLEEAVRN 1090 ATRHPGAAPM 1100 PVHPPPPGPR 1110 EPAQQGPTPS 1120 RVELDDSDVF 1130 HGEPEPEELP 1140 GGTGSQQRVQ 1150 GKHQVLLEDP 1160 EQEGSAEEEE 1170 LGVLPCPSTS 1180 LDGENRGIRT 1190 RNPIHLAFPG 1200 PLFMEGLADS 1210 ALEDVENLRH 1220 LILWSLLPGH 1230 TMETQAAQEP 1240 EDDLTPTPSV 1250 ISVTSHPWDP 1260 GSPGQAPPGG 1270 EGDNTQLAGL 1280 EGERPEQEDM 1290 GLCSLEHLPP 1300 RTRNSGIWES 1310 PELDRNLAED 1320 ASSTEAAGGY 1330 KVVRKAEVAG 1340 SKVVPALPES 1350 GQSEPGPPEV 1360 EGGTKATGNC 1370 FYVSMPSGPP 1380 DSSTDHSEAP 1390 MSPPQPDSLP 1400 AGQTEPQPQL 1410 QGGNDDPRRP 1420 SRSPPSLALR 1430 DVGMIFHTIE 1440 QLTLKLNRLK 1450 DMELAHRELL 1460 KSLGGESSGG 1470 TTPVGSFHTE 1480 AARWTDGSLS 1490 PPAKEPLASD 1500 SRNSHELGPC 1510 PEDGSDAPLE 1520 DSTADAAASP GP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0001664 G protein-coupled receptor binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0006941 striated muscle contraction

Reference

PMID: N/A